Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.52 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.50 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 2/20 | 0.47 |
| ▸ | PRKX | P51817 | 2/20 | 0.47 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.47 |
| ▸ | GRK5 | P34947 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7018465 | 0.88 | EGLN1 (0.59) | MAPTLMNAHPGDKMT2ASUCNR1 | |
| SCHEMBL7017409 | 0.84 | EGLN1 (0.53) | MAPTLMNAKMT2ASUCNR1EGLN1 | |
| SCHEMBL7010267 | 0.83 | LMNA (0.61) | MAPTLMNATP53THRBHPGD | |
| SCHEMBL7014974 | 0.83 | MAPT (0.49) | MAPTLMNATP53HPGDKMT2A | |
| SCHEMBL7014015 | 0.83 | PTPN1 (0.47) | MAPTLMNATP53THRBKMT2A | |
| SCHEMBL7021606 | 0.81 | EPHX1 (0.52) | MAPTLMNAKMT2AALDH1A1HTT | |
| SCHEMBL8475706 | 0.79 | LMNA (0.51) | MAPTLMNATP53THRBHPGD | |
| SCHEMBL7011724 | 0.78 | MEN1 (0.51) | LMNAHPGDKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL617423 | 0.77 | KMT2A (0.62) | MAPTLMNATP53THRBHPGD | |
| SCHEMBL7019228 | 0.77 | ROCK2 (0.48) | MAPTLMNATP53HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1155017-B1 | [1,8] NAPHTHYRIDINE DERIVATIVES HAVING ANTIVIRAL ACTIVITY | SHIRE BIOCHEM INC (CA) | 2003-01-15 | — | — | EP | claimed |