Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NOS3 | P29474 | 2/20 | 0.38 |
| ▸ | NOS1 | P29475 | 2/20 | 0.38 |
| ▸ | NOS2 | P35228 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.37 |
| ▸ | CFD | P00746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7019552 | 1.00 | PRMT6 (0.39) | PRMT6HRH3ALDH1A1NOS3NOS1 | |
| SCHEMBL7017707 | 0.84 | SLC9A1 (0.46) | ALDH1A1NOS3NOS1NOS2SMN1; SMN2 | |
| SCHEMBL4607572 | 0.79 | GRIA4 (0.47) | SIRT2SIRT1 | |
| SCHEMBL4606839 | 0.78 | KCNQ3 (0.50) | HRH3ALDH1A1SIRT2SIRT1 | |
| SCHEMBL3323648 | 0.75 | KCNQ3 (0.54) | HRH3ALDH1A1 | |
| SCHEMBL25359641 | 0.73 | PRMT6 (0.44) | PRMT6TPSAB1ENPP2LOXL2 | |
| SCHEMBL30531117 | 0.73 | PRMT6 (0.44) | PRMT6TPSAB1ENPP2LOXL2 | |
| SCHEMBL4608450 | 0.72 | GRIA4 (0.46) | SMN1; SMN2SIRT2SIRT1 | |
| Formic Acid SCHEMBL27536013 | 0.72 | TPSAB1 (0.45) | CYP3A4TPSAB1ENPP2 | |
| Hydrochloric Acid SCHEMBL15922780 | 0.72 | TPSAB1 (0.43) | PRMT6TPSAB1ENPP2LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368341-A1 | PHENYL DERIVATIVES 3 | MERCK PATENT GmbH (DE) | 2003-12-10 | — | — | EP | claimed |
| WO-2002074765-A1 | PHENYL DERIVATIVES 3 | MERCK PATENT GMBH (DE) | 2002-09-26 | — | — | WO | claimed |
| EP-1368341-A1 | PHENYL DERIVATIVES 3 | MERCK PATENT GmbH (DE) | 2003-12-10 | — | — | EP | disclosed |
| WO-2002074765-A1 | PHENYL DERIVATIVES 3 | MERCK PATENT GMBH (DE) | 2002-09-26 | — | — | WO | disclosed |