Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.46 |
| ▸ | DRD3 | P35462 | 3/20 | 0.46 |
| ▸ | HTR6 | P50406 | 2/20 | 0.45 |
| ▸ | PLAU | P00749 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7023748 | 1.00 | DRD2 (0.46) | DRD2DRD3HTR6PLAUSIGMAR1 | |
| SCHEMBL7240418 | 0.81 | ADRA1A (0.64) | DRD2DRD3ADRA1A | |
| SCHEMBL7240416 | 0.81 | ADRA1A (0.64) | DRD2DRD3ADRA1A | |
| SCHEMBL7025288 | 0.78 | DRD3 (0.47) | DRD2DRD3HTR6PLAUSIGMAR1 | |
| SCHEMBL6816574 | 0.78 | DRD3 (0.47) | DRD2DRD3HTR6PLAUSIGMAR1 | |
| SCHEMBL4788557 | 0.78 | DRD3 (0.47) | DRD2DRD3HTR6PLAUSIGMAR1 | |
| SCHEMBL4786874 | 0.76 | DRD2 (0.52) | DRD2DRD3PLAUADRA1A | |
| SCHEMBL4747507 | 0.76 | HTR6 (0.40) | DRD2DRD3HTR6HTR1A | |
| SCHEMBL7029083 | 0.73 | DRD2 (0.47) | DRD2DRD3HTR6 | |
| SCHEMBL14591309 | 0.73 | PLAU (0.55) | DRD2DRD3PLAUADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888319-B1 | SUBSTITUTED 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | disclosed |
| US-6410530-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | ASTRAZENECA AB (SE) | 2002-06-25 | — | — | US | disclosed |
| US-6124283-A | Substituted 1,2,3,4-tetrahydronaphthalene derivatives | ASTRA AKTIEBOLAG (SE) | 2000-09-26 | — | — | US | disclosed |
| EP-0888319-A1 | SUBSTITUTED 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES | Astra Aktiebolag (SE) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997034883-A1 | SUBSTITUTED 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES | ASTRA AKTIEBOLAG (SE) | 1997-09-25 | — | — | WO | disclosed |