SCHEMBL70247

SCHEMBL70247

Nc1ccc(-c2ncon2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 6/20 0.48
MEN1 O00255 6/20 0.48
KMT2A Q03164 6/20 0.48
NPC1 O15118 5/20 0.48
ALDH1A1 P00352 4/20 0.48
MAPT P10636 4/20 0.48
HPGD P15428 3/20 0.48
HSD17B10 Q99714 3/20 0.48
SMN1; SMN2 Q16637 3/20 0.48
TP53 P04637 2/20 0.48
KDM4E B2RXH2 2/20 0.48
CYP3A4 P08684 2/20 0.42
TDP1 Q9NUW8 2/20 0.42
KMO O15229 1/20 0.40
CYP19A1 P11511 1/20 0.38
ACHE P22303 2/20 0.37
PPARA Q07869 1/20 0.37
BCHE P06276 1/20 0.36
PIK3R1 P27986 1/20 0.36
PIK3CA P42336 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1188116 0.78 MEN1 (0.50) RAB9AMEN1KMT2ANPC1ALDH1A1
SCHEMBL28481167 0.78 RAB9A (0.46) RAB9AMEN1KMT2ANPC1ALDH1A1
SCHEMBL8590923 0.78 KMO (0.40) KMOPPARAMETAP2APP
SCHEMBL19356875 0.78 KMO (0.40) KMOPPARA
SCHEMBL3398203 0.78 KMO (0.47) RAB9AMEN1KMT2ANPC1MAPT
SCHEMBL2740475 0.78 NPC1 (0.40) RAB9AMEN1KMT2ANPC1HSD17B10
SCHEMBL6854121 0.78 NPC1 (0.43) RAB9AMEN1KMT2ANPC1ALDH1A1
SCHEMBL16907809 0.78 NR1H4 (0.44) RAB9AMEN1KMT2ANPC1ALDH1A1
SCHEMBL25447823 0.78 ADRB2 (0.55) NPC1ALDH1A1HPGDHSD17B10SMN1; SMN2
SCHEMBL14441201 0.78 NOTUM (0.44) RAB9ANPC1MAPTHPGDSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-121342814-A Preparation method of antiviral drug amoenavir 安徽峆一药业股份有限公司 2026-01-16 CN disclosed
CN-120820639-A Method for separating and detecting amotene Wei Qishi material 4- (1, 2, 4-oxadiazole-3-yl) aniline and impurities thereof 重庆凯林制药有限公司 2025-10-21 CN disclosed
CN-120820639-A Method for separating and detecting amotene Wei Qishi material 4- (1, 2, 4-oxadiazole-3-yl) aniline and impurities thereof 重庆凯林制药有限公司 2025-10-21 CN disclosed
CN-113149928-A Fluoro-1, 2, 4-oxadiazole-containing compound and preparation method and application thereof 青海省人民医院 2021-07-23 CN disclosed
WO-2020038812-A1 NEW PROCESS FOR THE PREPARATION OF AMENAMEVIR RIJKSUNIVERSITEIT GRONINGEN (NL) 2020-02-27 WO disclosed
WO-2020038812-A1 NEW PROCESS FOR THE PREPARATION OF AMENAMEVIR RIJKSUNIVERSITEIT GRONINGEN (NL) 2020-02-27 WO disclosed
EP-2978756-B1 SUBSTITUTED OXOPYRIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CARDIOVASCULAR DISEASES Bayer Pharma AG (DE) 2019-03-27 EP disclosed
US-10183932-B2 Substituted oxopyridine derivatives and use thereof cardiovascular disorders BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2019-01-22 US disclosed
EP-2593425-B1 THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE AGIOS PHARMACEUTICALS INC (US) 2018-10-17 EP disclosed
CN-108164513-A Substituted oxo pyridine derivative and its purposes in terms of cardiovascular disorder is treated 拜耳制药股份公司 2018-06-15 CN disclosed
US-20090239810-A1 NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE FOREST LABORATORIES HOLDINGS LIMITED (BM) 2009-09-24 US disclosed
US-20090239810-A1 NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE FOREST LABORATORIES HOLDINGS LIMITED (BM) 2009-09-24 US disclosed
WO-2009117676-A2 NOVEL PIPERIDINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE FOREST LABORATORIES HOLDINGS LIMITED (BM) 2009-09-24 WO disclosed
WO-2009117659-A1 NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE FOREST LABORATORIES HOLDINGS LIMITED (BM) 2009-09-24 WO disclosed
US-20060276433-A1 Hydrazone derivative DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2006-12-07 US disclosed
EP-1612204-A1 HYDRAZONE DERIVATIVE DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2006-01-04 EP disclosed
US-20050107456-A1 Substituted pyrazolines for use as pesticides BAYER CROPSCIENCE AG (DE) 2005-05-19 US disclosed
EP-1467971-A1 SUBSTITUTED PYRAZOLINES FOR USE AS PESTICIDES Bayer CropScience AG (DE) 2004-10-20 EP disclosed
WO-2003059887-A1 SUBSTITUTED PYRAZOLINES FOR USE AS PESTICIDES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2003-07-24 WO disclosed
US-4003909-A [(1,2,4-Oxadiazol-3-yl)phenyl]carbamic or thiocarbamic acid esters E. R. SQUIBB & SONS, INC. (US) 1977-01-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10183932-B2 Substituted oxopyridine derivatives and use thereof cardiovascular disorders OGFOD1, VASP, PNPO RAB9A 1862/4885MEN1 2573/4885KMT2A 3545/4885
US-20090239810-A1 NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE SCD, SCD5, FADS2 RAB9A 3858/4885MEN1 4884/4885KMT2A 1352/4885
US-20050107456-A1 Substituted pyrazolines for use as pesticides DDT, ACHE, CHRM1 RAB9A 353/4885MEN1 2809/4885KMT2A 3248/4885
US-20060276433-A1 Hydrazone derivative APP, PRNP, HTT RAB9A 3127/4885MEN1 3031/4885KMT2A 3533/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.