Sugi Predict

Sugi Predict / Compounds / SCHEMBL702638

SCHEMBL702638

SCHEMBL702638

Cc1ncc(C(=O)O)nc1C

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALOX15 P16050 3/20 0.48
▸ HPGD P15428 2/20 0.48
▸ ALDH1A1 P00352 2/20 0.48
▸ HSD17B10 Q99714 1/20 0.48
▸ KDM4E B2RXH2 8/20 0.46
▸ L3MBTL1 Q9Y468 3/20 0.46
▸ HCAR2 Q8TDS4 4/20 0.41
▸ KMT2A Q03164 1/20 0.41
▸ NAPRT Q6XQN6 2/20 0.40
▸ TDP1 Q9NUW8 2/20 0.39
▸ TSHR P16473 2/20 0.39
▸ ACMSD Q8TDX5 1/20 0.39
▸ P4HTM Q9NXG6 2/20 0.39
▸ P4HA1 P13674 1/20 0.39
▸ MIF P14174 1/20 0.39
▸ AKR1B1 P15121 1/20 0.39
▸ HIF1A Q16665 1/20 0.38
▸ PKM P14618 1/20 0.38
▸ DAO P14920 1/20 0.38
▸ SORT1 Q99523 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30112000 1.00 ALOX15 (0.48) ALOX15HPGDALDH1A1HSD17B10KDM4E
SCHEMBL29488827 0.83 ALDH1A1 (0.46) ALOX15HPGDALDH1A1HSD17B10KDM4E
SCHEMBL1105939 0.83 ALDH1A1 (0.46) ALOX15HPGDALDH1A1HSD17B10KDM4E
SCHEMBL4221972 0.83 ALDH1A1 (0.46) ALOX15HPGDALDH1A1HSD17B10KDM4E
SCHEMBL10335107 0.83 ALOX15 (0.46) ALOX15HPGDALDH1A1HSD17B10KDM4E
SCHEMBL26672964 0.83 ALOX15 (0.46) ALOX15HPGDALDH1A1HSD17B10KDM4E
SCHEMBL12606645 0.82 SMN1; SMN2 (0.41) ALOX15HPGDALDH1A1HSD17B10KDM4E
SCHEMBL25467254 0.81 ALDH1A1 (0.44) ALOX15HPGDALDH1A1HSD17B10KDM4E
SCHEMBL13588543 0.81 ALDH1A1 (0.44) ALOX15HPGDALDH1A1HSD17B10KDM4E
SCHEMBL1105943 0.81 ALOX15 (0.44) ALOX15HPGDALDH1A1HSD17B10KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3710428-B1 MODULATORS OF THE INTEGRATED STRESS PATHWAY CALICO LIFE SCIENCES LLC (US) 2026-03-25 — — EP disclosed
US-20240307382-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY ABBVIE INC. 2024-09-19 — — US disclosed
US-20240246946-A1 MODULATORS OF TREX1 CONSTELLATION PHARMACEUTICALS, INC. 2024-07-25 — — US disclosed
CN-112204009-B Modulators of integrated stress pathways 卡里科生命科学有限责任公司 2024-05-07 — — CN disclosed
EP-4330254-A1 MODULATORS OF TREX1 Constellation Pharmaceuticals, Inc. (US) 2024-03-06 — — EP disclosed
CN-117597333-A Heterocyclic compounds as receptor 2-triggering agonists expressed on myeloid cells and methods of use 维吉尔神经科学股份有限公司 2024-02-23 — — CN disclosed
CN-117545754-A Modulators of TREX1 星座制药公司 2024-02-09 — — CN disclosed
EP-3452456-B1 BICYCLIC MODULATORS OF THE INTEGRATED STRESS PATHWAY CALICO LIFE SCIENCES LLC (US) 2023-07-05 — — EP disclosed
CN-109641854-B Modulators of integrated stress pathways 卡里科生命科学有限责任公司 2023-02-03 — — CN disclosed
WO-2022232004-A1 MODULATORS OF TREX1 CONSTELLATION PHARMACEUTICALS, INC. (US) 2022-11-03 — — WO disclosed
EP-1659881-A2 NOVEL FLAVORS, FLAVOR MODIFIERS, TASTANTS, TASTE ENHANCERS, UMAMI OR SWEET TASTANTS, AND/OR ENHANCERS AND USE THEREOF Senomyx Inc. (US) 2006-05-31 — — EP disclosed
US-20060045953-A1 Aromatic amides and ureas and their uses as sweet and/or umami flavor modifiers, tastants and taste enhancers SENOMYX, INC. 2006-03-02 — — US disclosed
WO-2005041684-A2 NOVEL FLAVORS, FLAVOR MODIFIERS, TASTANTS, TASTE ENHANCERS, UMAMI OR SWEET TASTANTS, AND/OR ENHANCERS AND USE THEREOF SENOMYX INC. (US) 2005-05-12 — — WO disclosed
US-20050084506-A1 Amide compounds such as (R)-methyl 2-(3-chloro-4-methoxybenzamido)-4-methylpentanoate and urea compounds such as 1-(2-chlorophenyl)-3-(heptan-4-yl)urea for modulating taste of food or drug products FIRMENICH INCORPORATED 2005-04-21 — — US disclosed
US-4957640-A Corrosion prevention with compositions prepared from organic fatty amines and nitrogen-containing aromatic heterocyclic compounds THE DOW CHEMICAL COMPANY (US) 1990-09-18 — — US disclosed
US-4765839-A PAVING THE DOW CHEMICAL COMPANY (US) 1988-08-23 — — US disclosed
US-4761473-A CORROSION RESISTANCE OF OIL OR GAS WELLS THE DOW CHEMICAL COMPANY (US) 1988-08-02 — — US disclosed
US-4058611-A PYRAZINYL, BILHARZIASIS, AMOEBIASIS RHONE-POULENC INDUSTRIES (FR) 1977-11-15 — — US disclosed
US-4051245-A HYPOGLYCEMIC AND HYPOLIPAEMIC ACTIVITY CARLO ERBA, S.P.A. (IT) 1977-09-27 — — US disclosed
US-4002750-A HYPOGLYCEMIC AND HYPOLIPEMIC AGENTS CARLO ERBA S.P.A. (IT) 1977-01-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240246946-A1 MODULATORS OF TREX1 CFTR, SLC10A1, CYP27A1 ALOX15 1231/4885HPGD 735/4885ALDH1A1 693/4885
US-20240307382-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY ATF4, ATF1, DDIT3 ALOX15 639/4885HPGD 849/4885ALDH1A1 3433/4885
US-20050084506-A1 Amide compounds such as (R)-methyl 2-(3-chloro-4-methoxybenzamido)-4-methylpentanoate and urea compounds such as 1-(2-chlorophenyl)-3-(heptan-4-yl)urea for modulating taste of food or drug products TAS2R40, TAS2R4, TAS2R30 ALOX15 3301/4885HPGD 2006/4885ALDH1A1 1936/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.