Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CTSL | P07711 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 5/20 | 0.47 |
| ▸ | CTSB | P07858 | 4/20 | 0.47 |
| ▸ | CTSK | P43235 | 2/20 | 0.47 |
| ▸ | CTSH | P09668 | 1/20 | 0.47 |
| ▸ | CTSC | P53634 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8690337 | 0.81 | ALDH1A1 (0.47) | TSHRALDH1A1CTSLKMT2ACTSS | |
| SCHEMBL7445242 | 0.77 | KMT2A (0.59) | TSHRALDH1A1KMT2AGAALMNA | |
| SCHEMBL7028324 | 0.76 | CTSL (0.51) | TSHRALDH1A1CTSLKMT2ACTSS | |
| SCHEMBL7024515 | 0.76 | CTSS (0.75) | CTSLCTSSCTSBCTSKCTSH | |
| SCHEMBL7024509 | 0.76 | CTSS (0.75) | CTSLCTSSCTSBCTSKCTSH | |
| SCHEMBL7026009 | 0.76 | CTSS (0.75) | CTSLCTSSCTSBCTSKCTSH | |
| SCHEMBL7025999 | 0.76 | CTSS (0.75) | CTSLCTSSCTSBCTSKCTSH | |
| SCHEMBL7383287 | 0.76 | L3MBTL1 (0.42) | TSHRCTSLCTSBLMNA | |
| SCHEMBL7400048 | 0.75 | TGM2 (0.42) | CTSLKMT2A | |
| SCHEMBL7026935 | 0.75 | CTSL (0.77) | CTSLCTSSCTSBCTSKCTSH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002048097-A9 | COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF PARASITIC INFECTIONS | CORVAS INT INC (US) | 2003-05-08 | — | — | WO | disclosed |
| WO-2002048097-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF PARASITIC INFECTIONS | CORVAS INTERNATIONAL, INC. (US) | 2002-06-20 | — | — | WO | disclosed |