SCHEMBL703208

SCHEMBL703208

CCc1cccc([SiH2]Cl)c1CC

nearest known ligand 0.41

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 4/20 0.41
GABRB2 P47870 4/20 0.41
TAAR1 Q96RJ0 2/20 0.39
HTR1A P08908 3/20 0.36
KCNH2 Q12809 1/20 0.33
SCN5A Q14524 1/20 0.33
DRD2 P14416 2/20 0.32
DRD4 P21917 2/20 0.32
HTR2A P28223 2/20 0.32
HTR2C P28335 2/20 0.32
DRD3 P35462 2/20 0.32
PDK2 Q15119 1/20 0.31
MGLL Q99685 1/20 0.31
TP53 P04637 1/20 0.30
ALDH1A1 P00352 1/20 0.30
LMNA P02545 1/20 0.30
HTT P42858 1/20 0.30
DHFR P00374 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28646156 0.83 GABRA1 (0.40) GABRA1GABRB2TAAR1HTR1A
SCHEMBL29212521 0.81 CTRC (0.32)
SCHEMBL6114080 0.80 GABRA1 (0.41) GABRA1GABRB2MGLLTP53ALDH1A1
SCHEMBL21383327 0.79 GABRA1 (0.41) GABRA1GABRB2TAAR1HTR1AKCNH2
SCHEMBL706449 0.79 GABRA1 (0.46) GABRA1GABRB2TAAR1HTR1AKCNH2
SCHEMBL9745359 0.79 GABRA1 (0.46) GABRA1GABRB2TAAR1HTR1AKCNH2
SCHEMBL704995 0.79 GABRA1 (0.41) GABRA1GABRB2TAAR1HTR1AKCNH2
Chloromethane SCHEMBL27971188 0.77 GABRA1 (0.59) GABRA1GABRB2TAAR1HTR1AKCNH2
SCHEMBL245773 0.77 GABRA1 (0.57) GABRA1GABRB2TAAR1HTR1AKCNH2
SCHEMBL704074 0.76 ALDH1A1 (0.32) GABRA1GABRB2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3768732-A1 PROCESS FOR FUNCTIONALIZATION OF ORGANO-ZINC COMPOUNDS WITH HALOSILANES USING BASIC NITROGEN CONTAINING HETEROCYCLES AND SILYL-FUNCTIONALIZED COMPOUNDS PREPARED THEREBY Dow Global Technologies LLC (US) 2021-01-27 EP disclosed
EP-3768733-A1 SILICON-TERMINATED TELECHELIC POLYOLEFIN COMPOSITIONS AND PROCESSES FOR PREPARING THE SAME Dow Global Technologies LLC (US) 2021-01-27 EP disclosed
US-20210017195-A1 PROCESS FOR FUNCTIONALIZATION OF ORGANO-ZINC COMPOUNDS WITH HALOSILANES USING BASIC NITROGEN CONTAINING HETEROCYCLES AND SILYL-FUNCTIONALIZED COMPOUNDS PREPARED THEREBY DOW GLOBAL TECHNOLOGIES LLC (US) 2021-01-21 US disclosed
US-20210017311-A1 SILICON-TERMINATED TELECHELIC POLYOLEFIN COMPOSITIONS AND PROCESSES FOR PREPARING THE SAME DOW GLOBAL TECHNOLOGIES LLC 2021-01-21 US disclosed
CN-111868109-A Method for functionalizing organozinc compounds with halosilanes using basic nitrogen-containing heterocycles and silane-functionalized compounds prepared therefrom 陶氏环球技术有限责任公司 2020-10-30 CN disclosed
CN-111868110-A Silicon-terminated telechelic polyolefin compositions and methods of making the same 陶氏环球技术有限责任公司 2020-10-30 CN disclosed
WO-2019182992-A1 PROCESS FOR FUNCTIONALIZATION OF ORGANO-ZINC COMPOUNDS WITH HALOSILANES USING BASIC NITROGEN CONTAINING HETEROCYCLES AND SILYL-FUNCTIONALIZED COMPOUNDS PREPARED THEREBY DOW GLOBAL TECHNOLOGIES LLC (US) 2019-09-26 WO disclosed
WO-2019182993-A1 SILICON-TERMINATED TELECHELIC POLYOLEFIN COMPOSITIONS AND PROCESSES FOR PREPARING THE SAME DOW GLOBAL TECHNOLOGIES LLC (US) 2019-09-26 WO disclosed
EP-2912132-B1 CONTROLLED-RELEASE AMINE-CATALYZED, SULFUR-CONTAINING POLYMER AND EPOXY COMPOSITIONS PRC DESOTO INT INC (US) 2017-12-06 EP disclosed
EP-2912132-A2 CONTROLLED-RELEASE AMINE-CATALYZED, SULFUR-CONTAINING POLYMER AND EPOXY COMPOSITIONS PRC-Desoto International, Inc. (US) 2015-09-02 EP disclosed
US-9006360-B2 Controlled-release amine-catalyzed, sulfur-containing polymer and epdxy compositions PRC-DESOTO INTERNATIONAL, INC. (US) 2015-04-14 US disclosed
WO-2014066041-A2 CONTROLLED-RELEASE AMINE-CATALYZED, SULFUR-CONTAINING POLYMER AND EPOXY COMPOSITIONS PRC-DESOTO INTERNATIONAL, INC. (US) 2014-05-01 WO disclosed
US-20140110881-A1 CONTROLLED-RELEASE AMINE-CATALYZED, SULFUR-CONTAINING POLYMER AND EPOXY COMPOSITIONS PRC-DESOTO INTERNATIONAL, INC. 2014-04-24 US disclosed
US-8124239-B2 Silica film forming material, silica film and method of manufacturing the same, multilayer wiring structure and method of manufacturing the same, and semiconductor device and method of manufacturing the same FUJITSU LIMITED (JP) 2012-02-28 US disclosed
US-20100155121-A1 SILICA FILM FORMING MATERIAL, SILICA FILM AND METHOD OF MANUFACTURING THE SAME, MULTILAYER WIRING STRUCTURE AND METHOD OF MANUFACTURING THE SAME, AND SEMICONDUCTOR DEVICE AND METHOD OF MANUFACTURING THE SAME FUJITSU LIMITED (JP) 2010-06-24 US disclosed
US-7659357-B2 Precursor organosilicon polymer of 1,2-Bis(dimethylethoxysilyl)ethane, 1,4-bis(dimethylethoxysilyl)benzene, tetraethoxysilane, methyltriethoxysilane, phenyltriethoxysilane; dielectric (DE) films having etching/chemical/moisture resistance; adhesion; low DE constant; minimal wiring delay; high speed FUJITSU LIMITED (JP) 2010-02-09 US disclosed
US-20070026689-A1 Silica film forming material, silica film and method of manufacturing the same, multilayer wiring structure and method of manufacturing the same, and semiconductor device and method of manufacturing the same FUJITSU LIMITED (JP) 2007-02-01 US disclosed
EP-0012566-B1 ELECTRIC WINDINGS AND PRODUCTION THEREOF Hitachi, Ltd. (JP) 1983-06-22 EP disclosed
EP-0012566-A1 Electric windings and production thereof Hitachi, Ltd. (JP) 1980-06-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210017195-A1 PROCESS FOR FUNCTIONALIZATION OF ORGANO-ZINC COMPOUNDS WITH HALOSILANES USING BASIC NITROGEN CONTAINING HETEROCYCLES AND SILYL-FUNCTIONALIZED COMPOUNDS PREPARED THEREBY ZRANB2, NISCH, ZKSCAN2 GABRA1 2195/4885GABRB2 1665/4885TAAR1 2323/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.