Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7042097 | 0.86 | FAAH (0.36) | SMN1; SMN2NPC1RAB9AALDH1A1CYP2C19 | |
| SCHEMBL7678768 | 0.83 | CHRM4 (0.41) | ALDH1A1CHRM4KDM4EL3MBTL1 | |
| SCHEMBL11239164 | 0.82 | SMN1; SMN2 (0.39) | SMN1; SMN2NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL11239169 | 0.82 | SMN1; SMN2 (0.39) | SMN1; SMN2NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL7875061 | 0.81 | CHRM4 (0.51) | SMN1; SMN2NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL7335086 | 0.80 | OPRM1 (0.44) | ALDH1A1CHRM4MEN1KMT2AKDM4E | |
| SCHEMBL3128872 | 0.79 | GPR119 (0.61) | SMN1; SMN2MEN1KMT2AKDM4EGPR119 | |
| SCHEMBL11239659 | 0.78 | ALDH1A1 (0.36) | SMN1; SMN2NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL11239656 | 0.78 | ALDH1A1 (0.36) | SMN1; SMN2NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL3125608 | 0.76 | CARM1 (0.49) | SMN1; SMN2NPC1RAB9AALDH1A1CARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1060162-B1 | URETHANES DERIVED FROM AZACYCLOALKANES, THIO AND DITHIO ANALOGUES, PRODUCTION AND USE THEREOF AS 2,3 EPOXYSQUALENE LANESTEROL CYCLASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-03-19 | — | — | EP | disclosed |
| US-6339096-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERLIPIDAEMIAS, HYPERCHOLESTEROLAEMIAS AND ATHEROSCLEROSIS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-01-15 | — | — | US | disclosed |