SCHEMBL7040496

SCHEMBL7040496

Cc1cn([C@@]2(C(=O)c3ccc([N+](=O)[O-])cc3)C[C@H](O)[C@@H](CO)O2)c(=O)[nH]c1=O

nearest known ligand 0.44

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
TYMS P04818 1/20 0.37
TERT O14746 1/20 0.35
RNASE1 P07998 1/20 0.35
TK1 P04183 2/20 0.35
LGALS3 P17931 1/20 0.35
KDM4E B2RXH2 1/20 0.34
PKM P14618 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5709920 0.88 TK1 (0.40) RNASE1TK1
SCHEMBL5148089 0.87 RNASE1 (0.46) RNASE1TK1
SCHEMBL29927067 0.86 RNASE1 (0.39) TYMSRNASE1TK1
SCHEMBL8377337 0.85 LGALS3 (0.38) RNASE1TK1LGALS3KDM4E
SCHEMBL2543584 0.83 TYMS (0.39) TYMSTK1
SCHEMBL3694341 0.81 TK1 (0.43) RNASE1TK1
SCHEMBL9947616 0.81 TYMS (0.38) TYMSTK1
SCHEMBL6536213 0.81 TK1 (0.42) TK1
Phosphoric Acid SCHEMBL548541 0.80 TYMS (0.42) TYMSTK1
SCHEMBL28239487 0.80 TK1 (0.41) TK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0902788-B1 NUCLEOSIDE DERIVATIVES, AND THEIR USE IN OLIGONUCLEOTIDE SYNTHESIS CIS BIO INT (FR) 2003-03-19 EP disclosed
US-6197949-B1 SUPPORTS AND NOVEL PROCESSES FOR BINDING OLIGONUCLEOTIDES CIS BIO INTERNATIONAL (FR) 2001-03-06 US disclosed
US-6187914-B1 SOLID PHASE SYNTHESIS OF OLIGONUCLEOTIDES USING ELECTROCHEMICALLY LABILE PROTECTING GROUPS WHICH CAN BE REMOVED BY CREATING POTENTIAL DIFFERENCE BETWEEN WORKING ELECTRODE AND COUNTERELECTRODE CIS BIO INTERNATIONAL (FR) 2001-02-13 US disclosed
EP-0902788-A1 NUCLEOSIDE DERIVATIVES, AND THEIR USE IN OLIGONUCLEOTIDE SYNTHESIS CIS BIO INTERNATIONAL (FR) 1999-03-24 EP disclosed
US-5837859-A COPOLYMER AND NUCLEOTIDES OR HYBRIDS CIS BIO INTERNATIONAL (FR) 1998-11-17 US disclosed
WO-1997042207-A1 NUCLEOSIDE DERIVATIVES, AND THEIR USE IN OLIGONUCLEOTIDE SYNTHESIS CIS BIO INTERNATIONAL (FR) 1997-11-13 WO disclosed
EP-0691978-B1 ELECTRONICALLY CONDUCTIVE POLYMER/NUCLEOTIDE COPOLYMER, PREPARATION METHOD THEREFOR AND USE THEREOF CIS BIO INT (FR) 1997-10-08 EP disclosed
EP-0691978-A1 ELECTRONICALLY CONDUCTIVE POLYMER/NUCLEOTIDE COPOLYMER, PREPARATION METHOD THEREFOR AND USE THEREOF CIS BIO INT (FR) 1996-01-17 EP disclosed
WO-1994022889-A1 ELECTRONICALLY CONDUCTIVE POLYMER/NUCLEOTIDE COPOLYMER, PREPARATION METHOD THEREFOR AND USE THEREOF CIS BIO INTERNATIONAL (FR) 1994-10-13 WO disclosed