Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7040571 | 0.79 | LMNA (0.39) | ALDH1A1SMN1; SMN2GAAKMT2ANPSR1 | |
| SCHEMBL8484338 | 0.78 | PIN1 (0.34) | PIN1MMP8TDP1CASP1ALDH1A1 | |
| SCHEMBL7154293 | 0.77 | TSHR (0.37) | PIN1MMP8TDP1ALDH1A1L3MBTL1 | |
| SCHEMBL6337980 | 0.76 | ACP3 (0.37) | ALDH1A1L3MBTL1SMN1; SMN2MAPK1TSHR | |
| SCHEMBL8483313 | 0.75 | EPHX2 (0.36) | PIN1MMP8TDP1CASP1SMN1; SMN2 | |
| SCHEMBL639359 | 0.73 | ESR1 (0.35) | ALDH1A1SMN1; SMN2KDM4EGAAKMT2A | |
| SCHEMBL7040568 | 0.72 | CNR2 (0.33) | PIN1MMP8TDP1ALDH1A1L3MBTL1 | |
| SCHEMBL16672964 | 0.69 | GLA (0.49) | PIN1MMP8TDP1ALDH1A1L3MBTL1 | |
| SCHEMBL7045044 | 0.67 | RORC (0.38) | ALDH1A1SMN1; SMN2GAAKMT2ANPSR1 | |
| SCHEMBL7154295 | 0.67 | GAA (0.33) | PIN1MMP8TDP1ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0956286-B1 | SYNTHESIS OF TERFENADINE AND DERIVATIVES | SEPRACOR INC (US) | 2003-04-02 | — | — | EP | disclosed |
| US-6147217-A | Synthesis of terfenadine and derivatives | SEPRACOR INC. (US) | 2000-11-14 | — | — | US | disclosed |
| EP-0956286-A1 | SYNTHESIS OF TERFENADINE AND DERIVATIVES | SEPRACOR, INC. (US) | 1999-11-17 | — | — | EP | disclosed |
| WO-1998033789-A1 | SYNTHESIS OF TERFENADINE AND DERIVATIVES | SEPRACOR, INC. (US) | 1998-08-06 | — | — | WO | disclosed |