Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MMP8 | P22894 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7154295 | 0.80 | GAA (0.33) | CNR2KDM4EALDH1A1GAATDP1 | |
| SCHEMBL7040767 | 0.76 | CNR2 (0.39) | CNR2MAPK1MAPT | |
| SCHEMBL29905078 | 0.73 | KDM4E (0.39) | KDM4EALDH1A1GAATDP1MAPK1 | |
| SCHEMBL7040690 | 0.72 | PIN1 (0.33) | CNR2KDM4EALDH1A1GAATDP1 | |
| SCHEMBL8484338 | 0.70 | PIN1 (0.34) | KDM4EALDH1A1GAATDP1MAPK1 | |
| SCHEMBL20826480 | 0.69 | CNR2 (0.41) | CNR2ALDH1A1PIN1 | |
| SCHEMBL7154293 | 0.67 | TSHR (0.37) | KDM4EALDH1A1GAATDP1MAPK1 | |
| SCHEMBL20791050 | 0.65 | ALDH1A1 (0.37) | CNR2ALDH1A1KMT2AMAPTPIN1 | |
| SCHEMBL7040571 | 0.64 | LMNA (0.39) | CNR2ALDH1A1GAAKMT2ANPSR1 | |
| SCHEMBL17981630 | 0.64 | CA12 (0.46) | KDM4EALDH1A1GAATDP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0956286-B1 | SYNTHESIS OF TERFENADINE AND DERIVATIVES | SEPRACOR INC (US) | 2003-04-02 | — | — | EP | disclosed |
| US-6147217-A | Synthesis of terfenadine and derivatives | SEPRACOR INC. (US) | 2000-11-14 | — | — | US | disclosed |
| EP-0956286-A1 | SYNTHESIS OF TERFENADINE AND DERIVATIVES | SEPRACOR, INC. (US) | 1999-11-17 | — | — | EP | disclosed |
| WO-1998033789-A1 | SYNTHESIS OF TERFENADINE AND DERIVATIVES | SEPRACOR, INC. (US) | 1998-08-06 | — | — | WO | disclosed |