SCHEMBL7040935

SCHEMBL7040935

COc1nn(-c2ccc(OC(F)(F)F)cc2)c(=O)o1

nearest known ligand 0.68

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ABHD16A O95870 2/20 0.68
MGLL Q99685 3/20 0.65
FAAH O00519 1/20 0.65
LPL P06858 1/20 0.50
LIPC P11150 1/20 0.50
LIPE Q05469 1/20 0.50
ALDH1A1 P00352 1/20 0.48
NPBWR1 P48145 2/20 0.46
MCHR1 Q99705 2/20 0.46
L3MBTL1 Q9Y468 2/20 0.44
POLB P06746 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7046480 0.86 ABHD16A (0.50) ABHD16AMGLLFAAHLPLLIPC
SCHEMBL7044818 0.85 MGLL (0.55) ABHD16AMGLLFAAHLIPCLIPE
SCHEMBL7044272 0.85 MGLL (0.69) ABHD16AMGLLFAAHLPLLIPC
SCHEMBL7043025 0.83 ABHD16A (0.47) ABHD16AMGLLFAAHLIPCLIPE
SCHEMBL2703021 0.80 ABHD16A (0.44) ABHD16AMGLLFAAHLIPCLIPE
SCHEMBL2703657 0.80 ABHD16A (0.44) ABHD16AMGLLFAAHLIPCLIPE
SCHEMBL2701417 0.80 ABHD16A (0.44) ABHD16AMGLLFAAHLIPCLIPE
SCHEMBL2701728 0.80 ABHD16A (0.44) ABHD16AMGLLFAAHLIPCLIPE
SCHEMBL2701930 0.80 ABHD16A (0.44) ABHD16AMGLLFAAHLIPCLIPE
SCHEMBL2701842 0.80 ABHD16A (0.44) ABHD16AMGLLFAAHLIPCLIPE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20030236288-A1 Use of substituted 3-phenyl-5-alkoxy-3H-(1,3,4)-oxadizol-2-ones for inhibiting pancreatic lipase AVENTIS PHARMA DEUTSCHLAND GMBH 2003-12-25 US disclosed
US-6596742-B1 Inhibitory effect on the hormone-sensitive lipase, HSL. insecticides, controlling metabolism and multistage synthesis AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2003-07-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030236288-A1 Use of substituted 3-phenyl-5-alkoxy-3H-(1,3,4)-oxadizol-2-ones for inhibiting pancreatic lipase PNLIP, CEL, LIPE ABHD16A 62/4885MGLL 10/4885FAAH 142/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.