SCHEMBL7044818

SCHEMBL7044818

CCOc1nn(-c2ccc(OC(F)(F)F)cc2)c(=O)o1

nearest known ligand 0.55

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 2/20 0.55
BCHE P06276 1/20 0.52
LIPC P11150 1/20 0.52
ACHE P22303 1/20 0.52
LIPE Q05469 1/20 0.52
ABHD16A O95870 1/20 0.49
FAAH O00519 1/20 0.48
NPBWR1 P48145 2/20 0.41
MCHR1 Q99705 2/20 0.41
POLB P06746 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
CACNA2D1 P54289 1/20 0.41
ALDH1A1 P00352 1/20 0.41
SLC5A1 P13866 1/20 0.40
SLC5A2 P31639 1/20 0.40
TEAD1 P28347 1/20 0.39
TEAD4 Q15561 1/20 0.39
TEAD2 Q15562 1/20 0.39
TEAD3 Q99594 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7043025 0.90 ABHD16A (0.47) MGLLBCHELIPCACHELIPE
SCHEMBL2702375 0.87 ABHD16A (0.44) MGLLBCHELIPCACHELIPE
SCHEMBL2701417 0.87 ABHD16A (0.44) MGLLBCHELIPCACHELIPE
SCHEMBL2701930 0.87 ABHD16A (0.44) MGLLBCHELIPCACHELIPE
SCHEMBL2701728 0.87 ABHD16A (0.44) MGLLBCHELIPCACHELIPE
SCHEMBL2703021 0.87 ABHD16A (0.44) MGLLBCHELIPCACHELIPE
SCHEMBL2703657 0.87 ABHD16A (0.44) MGLLBCHELIPCACHELIPE
SCHEMBL2701842 0.87 ABHD16A (0.44) MGLLBCHELIPCACHELIPE
SCHEMBL7044396 0.86 MGLL (0.71) MGLLBCHELIPCACHELIPE
SCHEMBL7040935 0.85 ABHD16A (0.68) MGLLLIPCLIPEABHD16AFAAH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20030236288-A1 Use of substituted 3-phenyl-5-alkoxy-3H-(1,3,4)-oxadizol-2-ones for inhibiting pancreatic lipase AVENTIS PHARMA DEUTSCHLAND GMBH 2003-12-25 US claimed
US-20030236288-A1 Use of substituted 3-phenyl-5-alkoxy-3H-(1,3,4)-oxadizol-2-ones for inhibiting pancreatic lipase AVENTIS PHARMA DEUTSCHLAND GMBH 2003-12-25 US disclosed
US-6596742-B1 Inhibitory effect on the hormone-sensitive lipase, HSL. insecticides, controlling metabolism and multistage synthesis AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2003-07-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030236288-A1 Use of substituted 3-phenyl-5-alkoxy-3H-(1,3,4)-oxadizol-2-ones for inhibiting pancreatic lipase PNLIP, CEL, LIPE MGLL 10/4885BCHE 626/4885LIPC 7/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.