Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 8/20 | 0.71 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.67 |
| ▸ | NPC1 | O15118 | 5/20 | 0.60 |
| ▸ | RAB9A | P51151 | 4/20 | 0.60 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7040069 | 0.88 | NPC1 (0.64) | PARP1PARP2NPC1RAB9AMAPT | |
| SCHEMBL7112515 | 0.83 | PARP1 (1.00) | PARP1PARP2NPC1RAB9A | |
| SCHEMBL7111338 | 0.83 | PARP1 (0.80) | PARP1PARP2ALDH1A1 | |
| SCHEMBL424209 | 0.82 | PARP1 (0.81) | PARP1PARP2NPC1RAB9ACASP1 | |
| SCHEMBL7045309 | 0.82 | PARP1 (0.78) | PARP1PARP2ALDH1A1 | |
| SCHEMBL31602072 | 0.82 | PARP1 (0.81) | PARP1PARP2NPC1RAB9ACASP1 | |
| SCHEMBL7042977 | 0.82 | PARP1 (0.78) | PARP1PARP2CASP1KMT2A | |
| SCHEMBL7108289 | 0.80 | PARP1 (1.00) | PARP1PARP2CASP1 | |
| SCHEMBL7107333 | 0.79 | PARP1 (1.00) | PARP1PARP2CASP1 | |
| SCHEMBL7045177 | 0.79 | PARP1 (1.00) | PARP1PARP2NPC1RAB9ACASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003007959-A1 | QUINOXALINE DERIVATIVES WHICH HAVE PARP INHIBITORY ACTION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-01-30 | — | — | WO | disclosed |