Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PRKCA | P17252 | 1/20 | 0.37 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.37 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 3/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7046813 | 0.96 | FLT3 (0.44) | FLT3PIM1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7043340 | 0.88 | CHRNB2 (0.39) | PRKCAPRKCQPRKCDCHRNB2CHRNA4 | |
| SCHEMBL5622106 | 0.85 | FLT3 (0.44) | FLT3PIM1PRKCAPRKCQPRKCD | |
| SCHEMBL7042010 | 0.84 | FLT3 (0.41) | FLT3PIM1CHRNB2CHRNA4CYP1A2 | |
| SCHEMBL7043722 | 0.83 | MEN1 (0.37) | MEN1KMT2ASOS1HTR3A | |
| SCHEMBL7044695 | 0.81 | HTR3A (0.40) | PIM1PRKCAPRKCQPRKCDCHRNB2 | |
| SCHEMBL7036855 | 0.81 | HTR3A (0.40) | PIM1PRKCAPRKCQPRKCDCHRNB2 | |
| SCHEMBL7045753 | 0.81 | HTR3A (0.38) | CHRNB2CHRNA4CYP1A2CYP2C9MEN1 | |
| SCHEMBL7042936 | 0.81 | MEN1 (0.38) | CYP1A2CYP2C9CYP2C19MEN1KMT2A | |
| SCHEMBL7038476 | 0.80 | MEN1 (0.40) | CYP1A2CYP2C9CYP2C19MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133477-B1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | ABBOTT GMBH & CO KG (DE) | 2004-02-18 | — | — | EP | disclosed |