Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 6/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7045272 | 0.96 | FLT3 (0.44) | FLT3KCNH2PIM1SOS1HTR3A | |
| SCHEMBL7036855 | 0.89 | HTR3A (0.40) | PIM1SOS1HTR3ACHRNB2CHRNA4 | |
| SCHEMBL7044695 | 0.89 | HTR3A (0.40) | PIM1SOS1HTR3ACHRNB2CHRNA4 | |
| SCHEMBL7045753 | 0.89 | HTR3A (0.38) | SOS1HTR3ACHRNB2CHRNA4KMT2A | |
| SCHEMBL7043340 | 0.88 | CHRNB2 (0.39) | HTR3ACHRNB2CHRNA4KMT2AMEN1 | |
| SCHEMBL7046777 | 0.87 | HTR3A (0.39) | HTR3ACHRNB2CHRNA4 | |
| SCHEMBL7037841 | 0.87 | HTR3A (0.38) | HTR3AKMT2AMEN1 | |
| SCHEMBL7042935 | 0.85 | HTR3A (0.42) | KCNH2PIM1SOS1HTR3A | |
| SCHEMBL5621918 | 0.85 | PARP1 (0.44) | FLT3KCNH2PIM1CHRNB2CHRNA4 | |
| SCHEMBL7042964 | 0.85 | HTR3A (0.42) | KCNH2PIM1SOS1HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133477-B1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | ABBOTT GMBH & CO KG (DE) | 2004-02-18 | — | — | EP | disclosed |