Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 9/20 | 0.71 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.67 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.57 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.57 |
| ▸ | DHODH | Q02127 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | ATR | Q13535 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7111338 | 0.89 | PARP1 (0.80) | PARP1PARP2PKN1PKN2DHODH | |
| SCHEMBL7112515 | 0.83 | PARP1 (1.00) | PARP1PARP2PKN1PKN2DHODH | |
| SCHEMBL20660475 | 0.83 | PARP1 (0.60) | PARP1PARP2KMT2AATR | |
| SCHEMBL7113559 | 0.83 | PARP1 (0.67) | PARP1PARP2KMT2ARXFP1 | |
| SCHEMBL7042977 | 0.82 | PARP1 (0.78) | PARP1PARP2DHODHKMT2ARXFP1 | |
| SCHEMBL424209 | 0.82 | PARP1 (0.81) | PARP1PARP2DHODHKMT2AATR | |
| SCHEMBL31602072 | 0.82 | PARP1 (0.81) | PARP1PARP2DHODHKMT2AATR | |
| SCHEMBL7045309 | 0.82 | PARP1 (0.78) | PARP1PARP2DHODHMAPK1ATR | |
| SCHEMBL7108289 | 0.80 | PARP1 (1.00) | PARP1PARP2ATR | |
| SCHEMBL7046986 | 0.80 | PARP1 (0.70) | PARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003007959-A1 | QUINOXALINE DERIVATIVES WHICH HAVE PARP INHIBITORY ACTION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-01-30 | — | — | WO | claimed |
| WO-2003007959-A1 | QUINOXALINE DERIVATIVES WHICH HAVE PARP INHIBITORY ACTION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-01-30 | — | — | WO | disclosed |