Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 11/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7046082 | 0.95 | P2RX7 (0.44) | HTR4P2RX7 | |
| SCHEMBL7046652 | 0.95 | P2RX7 (0.47) | HTR4P2RX7 | |
| SCHEMBL6746510 | 0.94 | P2RX7 (0.48) | HTR4P2RX7 | |
| SCHEMBL4610877 | 0.78 | KMT2A (0.51) | — | |
| SCHEMBL4613206 | 0.76 | MEN1 (0.41) | — | |
| SCHEMBL7044113 | 0.76 | ALDH1A1 (0.52) | — | |
| SCHEMBL7047164 | 0.76 | CA2 (0.52) | — | |
| SCHEMBL4612617 | 0.76 | MEN1 (0.52) | — | |
| SCHEMBL4611362 | 0.75 | TP53 (0.52) | — | |
| SCHEMBL7046760 | 0.74 | MEN1 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1460064-A1 | Indole-2-carboxamide derivatives useful as beta-2 agonists | Pfizer Limited (GB) | 2004-09-22 | — | — | EP | claimed |
| EP-1460064-A1 | Indole-2-carboxamide derivatives useful as beta-2 agonists | Pfizer Limited (GB) | 2004-09-22 | — | — | EP | disclosed |