Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GALR3 | O60755 | 1/20 | 0.45 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7047164 | 0.86 | CA2 (0.52) | KMT2AALDH1A1MAPT | |
| SCHEMBL7039562 | 0.84 | RORC (0.54) | ALDH1A1 | |
| SCHEMBL4613206 | 0.80 | MEN1 (0.41) | KMT2AMEN1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL7044113 | 0.80 | ALDH1A1 (0.52) | KMT2AMEN1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL4612617 | 0.79 | MEN1 (0.52) | KMT2AMEN1ALDH1A1KDM4EHTT | |
| SCHEMBL4611362 | 0.78 | TP53 (0.52) | KMT2AMEN1THRBSMN1; SMN2LMNA | |
| SCHEMBL6746550 | 0.78 | NTRK1 (0.41) | KMT2AMEN1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL7046082 | 0.76 | P2RX7 (0.44) | KMT2ASMN1; SMN2RAB9AKDM4ENPC1 | |
| SCHEMBL7046652 | 0.76 | P2RX7 (0.47) | KMT2AMEN1SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL6746510 | 0.76 | P2RX7 (0.48) | KMT2AMEN1SMN1; SMN2KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1556034-B1 | INDOLE DERIVATIVES AS BETA-2 AGONISTS | PFIZER LTD (GB) | 2008-04-16 | — | — | EP | claimed |
| EP-1440966-A1 | Indole derivatives useful for the treatment of diseases | Pfizer Limited (GB) | 2004-07-28 | — | — | EP | claimed |
| US-20040116503-A1 | Indole derivatives useful for the treatment of diseases | PFIZER INC. | 2004-06-17 | — | — | US | claimed |
| EP-1556034-B1 | INDOLE DERIVATIVES AS BETA-2 AGONISTS | PFIZER LTD (GB) | 2008-04-16 | — | — | EP | disclosed |
| EP-1440966-A1 | Indole derivatives useful for the treatment of diseases | Pfizer Limited (GB) | 2004-07-28 | — | — | EP | disclosed |