Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4612617 | 0.90 | MEN1 (0.52) | MEN1KMT2ATSHRHPGDTP53 | |
| SCHEMBL4611362 | 0.83 | TP53 (0.52) | MEN1KMT2AHPGDTP53MAPT | |
| SCHEMBL4610877 | 0.80 | KMT2A (0.51) | MEN1KMT2AHPGDMAPTHTT | |
| SCHEMBL7044113 | 0.78 | ALDH1A1 (0.52) | MEN1KMT2ATSHRHPGDTP53 | |
| SCHEMBL4613210 | 0.77 | NPSR1 (0.48) | MEN1KMT2ATSHRHPGDTP53 | |
| SCHEMBL7047164 | 0.77 | CA2 (0.52) | KMT2AMAPTALDH1A1 | |
| SCHEMBL7039562 | 0.76 | RORC (0.54) | ALDH1A1 | |
| SCHEMBL6746550 | 0.76 | NTRK1 (0.41) | MEN1KMT2ATSHRHPGDTP53 | |
| SCHEMBL7046082 | 0.75 | P2RX7 (0.44) | KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL7046652 | 0.75 | P2RX7 (0.47) | MEN1KMT2ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1556034-B1 | INDOLE DERIVATIVES AS BETA-2 AGONISTS | PFIZER LTD (GB) | 2008-04-16 | — | — | EP | claimed |
| EP-1440966-A1 | Indole derivatives useful for the treatment of diseases | Pfizer Limited (GB) | 2004-07-28 | — | — | EP | claimed |
| US-20040116503-A1 | Indole derivatives useful for the treatment of diseases | PFIZER INC. | 2004-06-17 | — | — | US | claimed |
| EP-1556034-B1 | INDOLE DERIVATIVES AS BETA-2 AGONISTS | PFIZER LTD (GB) | 2008-04-16 | — | — | EP | disclosed |
| EP-1556034-A1 | INDOLE DERIVATIVES AS BETA-2 AGONISTS | Pfizer Limited (GB) | 2005-07-27 | — | — | EP | disclosed |
| EP-1440966-A1 | Indole derivatives useful for the treatment of diseases | Pfizer Limited (GB) | 2004-07-28 | — | — | EP | disclosed |
| WO-2004032921-A1 | INDOLE DERIVATIVES AS BETA-2 AGONISTS | PFIZER LIMITED (GB) | 2004-04-22 | — | — | WO | disclosed |