Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | UBE2N | P61088 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PLEC | Q15149 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7158730 | 0.92 | RAB9A (0.46) | TP53TSHRMAPK1UBE2NRAB9A | |
| SCHEMBL7047535 | 0.87 | MRGPRX4 (0.41) | TP53RAB9AMAPTSMN1; SMN2HTT | |
| SCHEMBL7050361 | 0.84 | TSHR (0.43) | TP53TSHRMAPK1UBE2NRAB9A | |
| SCHEMBL7045477 | 0.82 | CCR2 (0.44) | RAB9AMAPTLMNASMN1; SMN2HTT | |
| SCHEMBL7051845 | 0.80 | ABCB11 (0.40) | RAB9AMAPTLMNASMN1; SMN2GAA | |
| SCHEMBL7046362 | 0.77 | HDAC1 (0.51) | TP53TSHRMAPK1UBE2NRAB9A | |
| SCHEMBL7048128 | 0.77 | CCR2 (0.45) | RAB9AMAPTLMNASMN1; SMN2HTT | |
| SCHEMBL7050840 | 0.75 | CCR2 (0.41) | RAB9AMAPTLMNASMN1; SMN2HTT | |
| SCHEMBL7050228 | 0.73 | CCR2 (0.39) | RAB9AMAPTLMNASMN1; SMN2HTT | |
| SCHEMBL7954542 | 0.73 | CCR2 (0.39) | RAB9AMAPTLMNASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054667-B1 | BICYCLIC PYRROLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS ANTIINFLAMMATORY AND IMMUNOMODULATING AGENTS | ASTRAZENECA UK LTD (GB) | 2003-04-16 | — | — | EP | disclosed |