SCHEMBL7047776

SCHEMBL7047776

C#Cc1ccccc1C(=O)Nc1ccccc1S(N)(=O)=O.c1cc2ccc1-2

nearest known ligand 0.51

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CA1 P00915 15/20 0.51
CA2 P00918 15/20 0.51
CA9 Q16790 5/20 0.48
CA12 O43570 2/20 0.47
F10 P00742 2/20 0.42
KLK1 P06870 1/20 0.42
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42
KMT2A Q03164 1/20 0.42
CA6 P23280 1/20 0.42
CA5A P35218 1/20 0.42
CA7 P43166 1/20 0.42
CA5B Q9Y2D0 1/20 0.42
KDM4E B2RXH2 1/20 0.42
USP2 O75604 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1083555 0.81 HDAC1 (0.50) NPC1RAB9AKDM4E
SCHEMBL18132557 0.76 CA1 (0.62) CA1CA2CA9CA12KMT2A
SCHEMBL6860157 0.76 CA2 (0.53) CA1CA2CA9CA12KMT2A
SCHEMBL6224506 0.74 CA1 (0.62) CA1CA2CA9CA12NPC1
SCHEMBL6866357 0.73 CA2 (0.51) CA1CA2CA9CA12
SCHEMBL7049830 0.72 HDAC1 (0.38) NPC1KMT2AKDM4E
SCHEMBL6551863 0.72 CA1 (0.55) CA1CA2CA9CA12NPC1
SCHEMBL6226263 0.71 CA1 (0.75) CA1CA2CA9CA12CA6
SCHEMBL7052347 0.71 HDAC1 (0.40) RAB9AKMT2AKDM4E
SCHEMBL6860565 0.71 CA2 (0.45) CA1CA2CA9CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20030191323-A1 Hypoglycemic agent AJINOMOTO CO., INC. (JP) 2003-10-09 US disclosed
US-20030162818-A1 Acylsulfonamide derivative AJINOMOTO CO. INC. (JP) 2003-08-28 US disclosed
US-6555584-B1 Acetyl-coa carboxylase inhibitors AJINOMOTO CO., INC. (JP) 2003-04-29 US disclosed
EP-1300142-A1 HYPOGLYCEMICS Ajinomoto Co., Inc. (JP) 2003-04-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030162818-A1 Acylsulfonamide derivative ACSS2, ACACA, FASN CA1 2192/4885CA2 2304/4885CA9 1240/4885
US-20030191323-A1 Hypoglycemic agent GPR119, IAPP, SLC5A2 CA1 2426/4885CA2 831/4885CA9 951/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.