Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL1938782 | 0.83 | POLB (0.42) | NR4A2GPR84KDM4EMEN1POLB | |
| Choline SCHEMBL7041896 | 0.81 | CSNK2A1 (0.38) | CSNK2A1 | |
| Phosphoric Acid SCHEMBL1232434 | 0.80 | GPR84 (0.50) | NR4A2GPR84MTNR1AMTNR1BGABRA1 | |
| Choline SCHEMBL7045796 | 0.79 | TDO2 (0.44) | GPR84HTR2A | |
| Choline SCHEMBL7047847 | 0.79 | GPR84 (0.43) | NR4A2GPR84SLC6A4IDO1 | |
| Choline SCHEMBL1938812 | 0.78 | — | — | |
| SCHEMBL1237991 | 0.76 | GPR84 (0.58) | NR4A2GPR84MTNR1AMTNR1BGABRA1 | |
| Acetic Acid SCHEMBL23525629 | 0.73 | NR4A2 (0.55) | NR4A2GPR84MTNR1AMTNR1BGABRA1 | |
| Acetic Acid SCHEMBL2543914 | 0.73 | NR4A2 (0.55) | NR4A2GPR84MTNR1AMTNR1BGABRA1 | |
| Choline SCHEMBL7044734 | 0.72 | CYP3A4 (0.44) | GPR84HTR2ASLC6A4KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6660494-B2 | Detecting phosphatidylcholine-specific phospholipase-C enzyme via incorporation of 3-indoxyl choline phosphate into substrate | BIOSYNTH AG (CH) | 2003-12-09 | — | — | US | disclosed |
| EP-1219628-B1 | Novel substrates for detection of microbial metabolites | BIOSYNTH AG (CH) | 2003-04-02 | — | — | EP | disclosed |
| US-20020151725-A1 | Detection of microbial metabolites | BIOYNTH AG (CH) | 2002-10-17 | — | — | US | disclosed |
| WO-2002051853-A1 | DETECTION OF MICROBIAL METABOLITES | BIOSYNTH AG (CH) | 2002-07-04 | — | — | WO | disclosed |
| EP-1219628-A1 | Novel substrates for detection of microbial metabolites | Biosynth AG (CH) | 2002-07-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020151725-A1 | Detection of microbial metabolites | LCT, CEL, PLCB1 | NR4A2 3624/4885GPR84 2820/4885MTNR1A 3308/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.