Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.42 |
| ▸ | WDR5 | P61964 | 1/20 | 0.42 |
| ▸ | ASPH | Q12797 | 1/20 | 0.42 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | FABP4 | P15090 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9419355 | 0.86 | RARA (0.49) | TSHR | |
| SCHEMBL29091677 | 0.86 | HSD17B10 (0.45) | TSHRHSD17B10LMNAL3MBTL1GAA | |
| SCHEMBL2592081 | 0.86 | L3MBTL1 (0.50) | TSHRHSD17B10LMNAL3MBTL1GAA | |
| SCHEMBL2338336 | 0.85 | PTPN11 (0.53) | TSHRLMNAKMT2ACYP3A4MEN1 | |
| SCHEMBL9191916 | 0.84 | PTPN11 (0.56) | TSHRLMNAKMT2ACYP3A4MEN1 | |
| SCHEMBL9164667 | 0.84 | PTPN11 (0.56) | TSHRLMNAKMT2ACYP3A4MEN1 | |
| SCHEMBL9407189 | 0.84 | PTPN11 (0.56) | TSHRLMNAKMT2ACYP3A4MEN1 | |
| SCHEMBL9341888 | 0.84 | KDM4E (0.42) | TSHRHSD17B10LMNAL3MBTL1GLA | |
| SCHEMBL29625882 | 0.83 | HSD17B10 (0.40) | TSHRHSD17B10LMNAL3MBTL1GAA | |
| SCHEMBL29625868 | 0.83 | HSD17B10 (0.40) | TSHRHSD17B10LMNAL3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124196-B2 | Fluorobicyclo[2.2.2]octane compound, method of producing the same, and applications thereof | FUJIFILM CORPORATION (JP) | 2012-02-28 | — | — | US | disclosed |
| US-8124196-B2 | Fluorobicyclo[2.2.2]octane compound, method of producing the same, and applications thereof | FUJIFILM CORPORATION (JP) | 2012-02-28 | — | — | US | disclosed |
| US-20100231844-A1 | FLUOROBICYCLO[2.2.2]OCTANE COMPOUND, METHOD OF PRODUCING THE SAME, AND APPLICATIONS THEREOF | FUJIFILM CORPORATION (JP) | 2010-09-16 | — | — | US | disclosed |
| US-20100231844-A1 | FLUOROBICYCLO[2.2.2]OCTANE COMPOUND, METHOD OF PRODUCING THE SAME, AND APPLICATIONS THEREOF | FUJIFILM CORPORATION (JP) | 2010-09-16 | — | — | US | disclosed |
| US-7442475-B2 | Cyanopyridone derivatives as liquid crystals | MERCK PATENT GMBH (DE) | 2008-10-28 | — | — | US | disclosed |
| US-7442475-B2 | Cyanopyridone derivatives as liquid crystals | MERCK PATENT GMBH (DE) | 2008-10-28 | — | — | US | disclosed |
| US-7442475-B2 | Cyanopyridone derivatives as liquid crystals | MERCK PATENT GMBH (DE) | 2008-10-28 | — | — | US | disclosed |
| US-20060165916-A1 | Cyanopyridone derivatives as liquid crystals | MERCK PATENT GMBH (DE) | 2006-07-27 | — | — | US | disclosed |
| EP-1594842-A1 | CYANOPYRIDONE DERIVATIVES AS LIQUID CRYSTALS | MERCK PATENT GmbH (DE) | 2005-11-16 | — | — | EP | disclosed |
| WO-2004074253-A1 | CYANOPYRIDONE DERIVATIVES AS LIQUID CRYSTALS | MERCK PATENT GMBH (DE) | 2004-09-02 | — | — | WO | disclosed |
| EP-1081123-A2 | 2,3-Difluorophenyl derivative having negative dielectric anisotropy, liquid crystal composition, and liquid crystal display device | CHISSO CORPORATION (JP) | 2001-03-07 | — | — | EP | disclosed |
| US-5595686-A | Silacyclohexane compounds, a liquid crystal composition comprising the same and a liquid crystal device comprising the composition | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1997-01-21 | — | — | US | disclosed |
| EP-0699683-A1 | Novel silacyclohexane compounds a liquid crystal composition comprising the same and a liquid crystal device comprising the composition | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1996-03-06 | — | — | EP | disclosed |
| EP-0363458-B1 | 2,3-DIFLUOROBENZENES | MERCK PATENT GMBH (DE) | 1994-08-03 | — | — | EP | disclosed |
| US-5279764-A | Dihalogenobenzene derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1994-01-18 | — | — | US | disclosed |
| US-5230827-A | DERIVATIVES OF 2,3-DIFLUOROBENZOIC ACID | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-07-27 | — | — | US | disclosed |
| EP-0358741-B1 | DERIVATIVES OF 2,3-DIFLUOROBENZOIC ACID | MERCK PATENT GmbH (DE) | 1993-02-10 | — | — | EP | disclosed |
| US-5087764-A | Deprotonation of a 1-substituted-2,3-difluorobenzene using an organometallic compound and reacting the reaction product with an electrophile | Merck Patent Gesellschaft mit beschrankter Hafung (DE) | 1992-02-11 | — | — | US | disclosed |
| EP-0358741-A1 | DERIVATIVES OF 2,3-DIFLUOROBENZOIC ACID. | MERCK PATENT GMBH (DE) | 1990-03-21 | — | — | EP | disclosed |
| WO-1989008688-A1 | DERIVATIVES OF 2,3-DIFLUOROBENZOIC ACID | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1989-09-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060165916-A1 | Cyanopyridone derivatives as liquid crystals | EPM2A, ACMSD, CSPP1 | TSHR 3268/4885HSD17B10 2440/4885LMNA 2872/4885 |
| US-20100231844-A1 | FLUOROBICYCLO[2.2.2]OCTANE COMPOUND, METHOD OF PRODUCING THE SAME, AND APPLICATIONS THEREOF | AFF2, FPR2, SLCO1A2 | TSHR 1377/4885HSD17B10 1426/4885LMNA 2238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.