Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Oxaloacetate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.44 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.44 |
| ▸ | OR51E2 | Q9H255 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 5/20 | 0.36 |
| ▸ | ERCC5 | P28715 | 4/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 1/20 | 0.34 |
| ▸ | FNTB | P49356 | 1/20 | 0.34 |
| ▸ | HAO1 | Q9UJM8 | 3/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxaloacetate SCHEMBL898612 | 0.87 | LDHA (0.57) | LDHASRROR51E2MAPK1SLC13A3 | |
| Oxaloacetate SCHEMBL8464 | 0.87 | — | — | |
| Oxaloacetate SCHEMBL4298763 | 0.87 | LDHA (0.57) | LDHASRROR51E2MAPK1SLC13A3 | |
| Oxaloacetate SCHEMBL6545252 | 0.84 | LDHA (0.53) | LDHASRROR51E2MAPK1SLC13A3 | |
| Oxaloacetate SCHEMBL8638879 | 0.84 | LDHA (0.53) | LDHASRROR51E2MAPK1SLC13A3 | |
| Oxaloacetate SCHEMBL25210523 | 0.84 | — | — | |
| Oxaloacetate SCHEMBL6545256 | 0.84 | LDHA (0.53) | LDHASRROR51E2MAPK1SLC13A3 | |
| Oxaloacetate SCHEMBL20912993 | 0.84 | LDHA (0.53) | LDHASRROR51E2MAPK1SLC13A3 | |
| Oxaloacetate SCHEMBL9782818 | 0.84 | LDHA (0.53) | LDHASRROR51E2MAPK1SLC13A3 | |
| Oxaloacetate SCHEMBL11328361 | 0.84 | LDHA (0.53) | LDHASRROR51E2MAPK1SLC13A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030036111-A1 | Mitochondrial protein | MEDICAL RESEARCH COUNCIL (GB) | 2003-02-20 | — | — | US | disclosed |