Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 6/20 | 0.46 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | AGXT | P21549 | 1/20 | 0.38 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7052637 | 0.85 | METAP2 (0.46) | PPARGPPARACSNK1ESLC15A1METAP2 | |
| SCHEMBL7050872 | 0.83 | IDO1 (0.50) | TAAR1CSNK1EIDO1METAP2 | |
| SCHEMBL7054865 | 0.81 | TAAR1 (0.43) | TAAR1CSNK1ESLC15A1IDO1METAP2 | |
| SCHEMBL7159796 | 0.80 | TAAR1 (0.52) | TAAR1IDO1AGXTMETAP2METAP1 | |
| SCHEMBL7340739 | 0.78 | EPHX1 (0.47) | TAAR1PPARGPPARACSNK1ESLC6A2 | |
| SCHEMBL7092247 | 0.78 | EPHX1 (0.58) | TAAR1SLC1A1CSNK1ESLC6A2MAOA | |
| SCHEMBL7092250 | 0.78 | EPHX1 (0.58) | TAAR1SLC1A1CSNK1ESLC6A2MAOA | |
| SCHEMBL7050427 | 0.77 | SIGMAR1 (0.43) | CSNK1ESIGMAR1SLC15A1METAP2METAP1 | |
| SCHEMBL7047857 | 0.77 | METAP2 (0.52) | TAAR1CSNK1ESLC6A2MAOASLC6A4 | |
| SCHEMBL3354800 | 0.76 | TAAR1 (0.46) | TAAR1SLC1A1MPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2004502669-A | — | — | 2004-01-29 | — | — | JP | claimed |
| EP-1353898-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2003-10-22 | — | — | EP | claimed |
| WO-2002002512-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2002-01-10 | — | — | WO | claimed |