Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.56 |
| ▸ | DRD3 | P35462 | 2/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | DRD1 | P21728 | 1/20 | 0.56 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7060114 | 0.95 | SIGMAR1 (0.56) | HTR1ASLC6A4DRD3ABCB11ADRA2A | |
| SCHEMBL11929304 | 0.82 | HTR1A (0.67) | HTR1ASLC6A4DRD3ABCB11ADRA2A | |
| SCHEMBL21669283 | 0.81 | HTR1A (0.67) | HTR1ASLC6A4DRD3ABCB11ADRA2A | |
| SCHEMBL7056301 | 0.80 | HTR1A (0.63) | HTR1ASLC6A4DRD3ABCB11ADRA2A | |
| SCHEMBL11162686 | 0.80 | SIGMAR1 (0.55) | HTR1ADRD3SIGMAR1DRD2ALDH1A1 | |
| SCHEMBL13533257 | 0.79 | HTR7 (0.61) | HTR1ASLC6A4DRD3ABCB11ADRA2A | |
| SCHEMBL2527416 | 0.79 | HTR1A (0.66) | HTR1ASLC6A4DRD3ABCB11ADRA2A | |
| SCHEMBL5654034 | 0.79 | HTR1A (0.66) | HTR1ASLC6A4DRD3ABCB11ADRA2A | |
| SCHEMBL2526228 | 0.79 | HTR1A (0.66) | HTR1ASLC6A4DRD3ABCB11ADRA2A | |
| SCHEMBL11151874 | 0.79 | SIGMAR1 (0.54) | HTR1ADRD3SIGMAR1DRD2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6521623-B1 | 1-(2-(4-(3-chlorophenyl)-1-piperazinyl)ethyl)-3-(2-hydroxyethyl) -1,3-dihydro-2H-benzimidazol-2-one for example; treating anxiety disorders and psychological disorders, brain injuries | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-02-18 | — | — | US | claimed |
| US-20030027823-A1 | N,N'-disubstituted benzimidazolone derivatives with affinity at the serotonin and dopamine receptors | Salix Pharmaceuticals, Ltd | 2003-02-06 | — | — | US | claimed |
| EP-1322622-B1 | NEW N, N'-DISUBSTITUTED BENZIMIDAZOLONE DERIVATIVES WITH AFFINITY AT THE SEROTONIN AND DOPAMINE RECEPTORS | SPROUT PHARMACEUTICALS INC (US) | 2012-10-31 | — | — | EP | disclosed |
| US-6521623-B1 | 1-(2-(4-(3-chlorophenyl)-1-piperazinyl)ethyl)-3-(2-hydroxyethyl) -1,3-dihydro-2H-benzimidazol-2-one for example; treating anxiety disorders and psychological disorders, brain injuries | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-02-18 | — | — | US | disclosed |
| US-20030027823-A1 | N,N'-disubstituted benzimidazolone derivatives with affinity at the serotonin and dopamine receptors | Salix Pharmaceuticals, Ltd | 2003-02-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030027823-A1 | N,N'-disubstituted benzimidazolone derivatives with affinity at the serotonin and dopamine receptors | OPRM1, HTR2C, HTR3C | HTR1A 5/4885SLC6A4 50/4885DRD3 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.