Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 7/20 | 0.43 |
| ▸ | NTMT1 | Q9BV86 | 2/20 | 0.42 |
| ▸ | ACE | P12821 | 5/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | FAP | Q12884 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5597236 | 0.90 | DPP4 (0.40) | F2ACEPRSS1PRSS2PRSS3 | |
| SCHEMBL3239444 | 0.88 | F2 (0.46) | F2NTMT1ACEPRSS1PRSS2 | |
| SCHEMBL29427848 | 0.77 | PDF (0.46) | F2NTMT1PRSS1PRSS2PRSS3 | |
| SCHEMBL263537 | 0.77 | PDF (0.46) | F2NTMT1PRSS1PRSS2PRSS3 | |
| Acetic Acid SCHEMBL16234756 | 0.77 | PDF (0.44) | F2NTMT1ACEPRSS1PRSS2 | |
| SCHEMBL2226082 | 0.77 | DPP4 (0.46) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7106909 | 0.76 | F2 (0.38) | F2ACEPRSS1PRSS2PRSS3 | |
| SCHEMBL29582281 | 0.75 | F2 (0.56) | F2NTMT1ACEACE2 | |
| SCHEMBL12955380 | 0.75 | DPP4 (0.42) | F2PRSS1PRSS2PRSS3LMNA | |
| SCHEMBL9603823 | 0.74 | DPP4 (0.44) | F2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307432-A1 | CYCLIC OXYGUANIDINE PROTEASE INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2003-05-07 | — | — | EP | disclosed |
| WO-2002012207-A1 | CYCLIC OXYGUANIDINE PROTEASE INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2002-02-14 | — | — | WO | disclosed |
| EP-1070049-A1 | BENZAMIDE AND SULFONAMIDE SUBSTITUTED AMINOGUANIDINES AND ALKOXYGUANIDINES AS PROTEASE INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2001-01-24 | — | — | EP | disclosed |
| US-5968782-A | NUCLEIC ACID SEQUENCE CODING POLYPEPTIDE ENZYME WITH ENTEROKINASE SENSITIVITY WHICH CAN BE USED FOR TREATING DISORDERS MEDIATED BY THROMBUS CLOT FORMATION | BRIGHAM AND WOMENS'S HOSPITAL, INC. (US) | 1999-10-19 | — | — | US | disclosed |
| WO-1999051571-A1 | BENZAMIDE AND SULFONAMIDE SUBSTITUTED AMINOGUANIDINES AND ALKOXYGUANIDINES AS PROTEASE INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 1999-10-14 | — | — | WO | disclosed |