Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29404005 | 0.97 | ACHE (0.53) | ACHELMNATSHRALOX12HPGD | |
| Iodide SCHEMBL7065210 | 0.95 | LMNA (0.50) | ACHELMNATSHRALOX12HPGD | |
| Bromide SCHEMBL7063570 | 0.95 | ACHE (0.50) | ACHELMNATSHRALOX12HPGD | |
| Hydrochloric Acid SCHEMBL7932457 | 0.89 | ACHE (0.53) | ACHELMNATSHRALOX12TDP1 | |
| SCHEMBL7065118 | 0.88 | ACHE (0.43) | ACHELMNATSHRALOX12HPGD | |
| SCHEMBL11314306 | 0.88 | ACHE (0.43) | ACHELMNATSHRALOX12HPGD | |
| Bromide SCHEMBL9181860 | 0.86 | ACHE (0.50) | ACHELMNATSHRALOX12TDP1 | |
| SCHEMBL503495 | 0.84 | TSHR (0.40) | ACHELMNATSHRALOX12HPGD | |
| Thiocyanic Acid SCHEMBL4447159 | 0.84 | ALDH1A1 (0.43) | ACHELMNATSHRALOX12HPGD | |
| SCHEMBL7065117 | 0.84 | ACHE (0.40) | ACHELMNATSHRALOX12HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9174918-B2 | Process for preparing diaryl oxalate | UBE INDUSTRIES, LTD. (JP) | 2015-11-03 | — | — | US | disclosed |
| US-20120296063-A1 | PROCESS FOR PREPARING DIARYL OXALATE | UBE CORPORATION (JP) | 2012-11-22 | — | — | US | disclosed |
| EP-1013633-B1 | Process for producing a diaryl carbonate | UBE INDUSTRIES (JP) | 2003-05-28 | — | — | EP | disclosed |
| EP-0832910-B1 | Process for producing a polycarbonate | UBE INDUSTRIES (JP) | 2002-06-26 | — | — | EP | disclosed |
| EP-0832872-B1 | Process for producing diaryl carbonate | UBE INDUSTRIES (JP) | 2002-01-30 | — | — | EP | disclosed |
| EP-0795539-B1 | Process for producing a diaryl carbonate | UBE INDUSTRIES (JP) | 2001-10-31 | — | — | EP | disclosed |
| EP-0834496-B1 | Preparation of diaryl carbonate | UBE INDUSTRIES (JP) | 2001-08-16 | — | — | EP | disclosed |
| EP-0834495-B1 | Process for preparing diaryl carbonate | UBE INDUSTRIES (JP) | 2000-12-27 | — | — | EP | disclosed |
| EP-1013633-A1 | Process for producing a diaryl carbonate | Ube Industries, Ltd. (JP) | 2000-06-28 | — | — | EP | disclosed |
| US-5922827-A | Process for producing a polycarbonate | UBE INDUSTRIES, LTD. (JP) | 1999-07-13 | — | — | US | disclosed |
| EP-0834496-A1 | Preparation of diaryl carbonate | UBE INDUSTRIES, LTD. (JP) | 1998-04-08 | — | — | EP | disclosed |
| EP-0832910-A2 | Process for producing a polycarbonate | UBE INDUSTRIES, LTD. (JP) | 1998-04-01 | — | — | EP | disclosed |
| EP-0832872-A1 | Process for producing diaryl carbonate | UBE INDUSTRIES, LTD. (JP) | 1998-04-01 | — | — | EP | disclosed |
| US-5731453-A | Process for producing a diaryl carbonate | UBE INDUSTRIES, LTD. (JP) | 1998-03-24 | — | — | US | disclosed |
| EP-0826658-A1 | Catalyst for decarbonylation reaction | UBE INDUSTRIES, LTD. (JP) | 1998-03-04 | — | — | EP | disclosed |
| EP-0795539-A1 | Process for producing a diaryl carbonate | UBE INDUSTRIES LIMITED (JP) | 1997-09-17 | — | — | EP | disclosed |
| US-5648510-A | DECARBONYLATION OF OXALATE | UBE INDUSTRIES, LTD. (JP) | 1997-07-15 | — | — | US | disclosed |
| EP-0737665-A1 | Process for preparation of diaryl carbonate | UBE INDUSTRIES, LTD. (JP) | 1996-10-16 | — | — | EP | disclosed |
| US-4324927-A | Process for the homologization of methanol | RHONE-POULENC INDUSTRIES (FR) | 1982-04-13 | — | — | US | disclosed |
| US-4306091-A | CATALYTIC HYDROCARBONYLATION OF METHANOL IN THE PRESENCE OF COBALT, RUTHENIUM AND AN ALKYL HALIDE AND AN IONIC HALIDE | RHONE-POULENC INDUSTRIES (FR) | 1981-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120296063-A1 | PROCESS FOR PREPARING DIARYL OXALATE | TH, CYP2E1, ADH1A | ACHE 671/4885LMNA 3146/4885TSHR 1038/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.