Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.72 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | GLA | P06280 | 1/20 | 0.69 |
| ▸ | PKM | P14618 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.67 |
| ▸ | GAA | P10253 | 3/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.63 |
| ▸ | GHSR | Q92847 | 1/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12600509 | 0.84 | SMN1; SMN2 (0.86) | TSHRPTGS2KMT2AGLAPKM | |
| SCHEMBL10333070 | 0.84 | TSHR (1.00) | TSHRPTGS2KMT2AGLAPKM | |
| SCHEMBL1225498 | 0.83 | PTGS2 (0.67) | TSHRPTGS2KMT2AGLAPKM | |
| SCHEMBL1224417 | 0.82 | ALDH1A1 (0.77) | TSHRPTGS2KMT2AGLAPKM | |
| SCHEMBL3451560 | 0.82 | TSHR (0.75) | TSHRPTGS2KMT2AGLAPKM | |
| SCHEMBL316185 | 0.82 | ALDH1A1 (0.76) | TSHRPTGS2KMT2AGLAPKM | |
| SCHEMBL11894104 | 0.81 | POLB (0.77) | TSHRPTGS2KMT2AGLAPKM | |
| SCHEMBL10333068 | 0.81 | TSHR (0.73) | TSHRPTGS2KMT2AGLAPKM | |
| SCHEMBL8722344 | 0.81 | TSHR (0.73) | TSHRPTGS2KMT2AGLAPKM | |
| SCHEMBL6342908 | 0.81 | ALDH1A1 (0.52) | TSHRPTGS2KMT2AGLAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030216459-A1 | Small-molecule modulators of hepatocyte growth factor / scatter factor activities | THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH | 2003-11-20 | — | — | US | disclosed |
| EP-1355921-A2 | MODULATORS OF CELLULAR PROLIFERATION AND ANGIOGENESIS, METHODS FOR USE AND IDENTIFICATION THEREOF | North Shore-Long Island Jewish Health System (US) | 2003-10-29 | — | — | EP | disclosed |
| WO-2002002593-A2 | MODULATORS OF CELLULAR PROLIFERATION AND ANGIOGENESIS, METHODS FOR USE AND IDENTIFICATION THEREOF | NORTH SHORE-LONG ISLAND JEWISH HEALTH SYSTEM (US) | 2002-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030216459-A1 | Small-molecule modulators of hepatocyte growth factor / scatter factor activities | HGF, HDGF, MET | TSHR 901/4885PTGS2 361/4885KMT2A 4257/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.