Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | GPR18 | Q14330 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7058690 | 0.89 | GAA (0.34) | ALDH1A1L3MBTL1MEN1CYP3A4CYP2C9 | |
| SCHEMBL7123002 | 0.85 | ALDH1A1 (0.38) | ALDH1A1TSHRMEN1CYP3A4CYP2C9 | |
| SCHEMBL7061898 | 0.85 | GAA (0.47) | ALDH1A1L3MBTL1MEN1CYP3A4CYP2C9 | |
| SCHEMBL6678209 | 0.79 | ALDH1A1 (0.38) | ALDH1A1L3MBTL1TSHRMEN1CYP3A4 | |
| SCHEMBL7062549 | 0.78 | ALDH1A1 (0.40) | ALDH1A1L3MBTL1MEN1CYP3A4CYP2C9 | |
| SCHEMBL7059284 | 0.78 | PTGS1 (0.34) | ALDH1A1L3MBTL1TSHRPTGS1PTGS2 | |
| SCHEMBL7061528 | 0.77 | ALDH1A1 (0.36) | ALDH1A1L3MBTL1TSHRMEN1CYP3A4 | |
| SCHEMBL7127312 | 0.76 | ALDH1A1 (0.49) | ALDH1A1L3MBTL1TSHRMEN1CYP3A4 | |
| SCHEMBL7125681 | 0.76 | L3MBTL1 (0.41) | ALDH1A1L3MBTL1MEN1KMT2AGAA | |
| SCHEMBL7119000 | 0.72 | MEN1 (0.40) | ALDH1A1L3MBTL1MEN1CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040224951-A1 | 5,6-Fused uracil derivatives as matrix metalloproteinase inhibitors | ROARK WILLIAM HOWARD (US) | 2004-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040224951-A1 | 5,6-Fused uracil derivatives as matrix metalloproteinase inhibitors | MMP9, MMP13, MMP25 | ALDH1A1 812/4885L3MBTL1 2277/4885TSHR 4003/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.