Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | LGMN | Q99538 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HPD | P32754 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7063104 | 0.85 | ALDH1A1 (0.37) | GAAL3MBTL1LMNAALDH1A1KMT2A | |
| SCHEMBL7127312 | 0.83 | ALDH1A1 (0.49) | GAAL3MBTL1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL7125681 | 0.83 | L3MBTL1 (0.41) | GAAL3MBTL1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL7119000 | 0.82 | MEN1 (0.40) | GAAL3MBTL1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL7115636 | 0.82 | KMT2A (0.49) | LMNAALDH1A1SMN1; SMN2PKMKMT2A | |
| SCHEMBL6683575 | 0.76 | GAA (0.46) | GAAL3MBTL1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL7058428 | 0.75 | SMN1; SMN2 (0.44) | LMNAALDH1A1SMN1; SMN2PKMRAB9A | |
| SCHEMBL7059744 | 0.73 | GAA (0.43) | GAAL3MBTL1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL6678512 | 0.67 | SMN1; SMN2 (0.45) | GAALMNAALDH1A1SMN1; SMN2PKM | |
| SCHEMBL7118303 | 0.67 | L3MBTL1 (0.41) | L3MBTL1LMNAALDH1A1SMN1; SMN2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040224951-A1 | 5,6-Fused uracil derivatives as matrix metalloproteinase inhibitors | ROARK WILLIAM HOWARD (US) | 2004-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040224951-A1 | 5,6-Fused uracil derivatives as matrix metalloproteinase inhibitors | MMP9, MMP13, MMP25 | GAA 358/4885L3MBTL1 2277/4885LMNA 3842/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.