Hydrochlorthiazide

Hydrochlorthiazide

SCHEMBL7063168

Nn1ccccc1=O.c1cscn1

nearest known ligand 0.33

Full drug profile on Sugi Atlas →

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
CA9 Q16790 1/20 0.33
CA14 Q9ULX7 1/20 0.33
ADORA3 P0DMS8 1/20 0.32
EP300 Q09472 1/20 0.30
KAT2B Q92831 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1397907 0.78
Anthraquinone SCHEMBL10486063 0.71 MAOA (0.50)
Anthraquinone SCHEMBL11057931 0.71 MAOA (0.50)
Hydrochlorthiazide SCHEMBL28813777 0.70 CYP3A4 (0.46)
Naphthalene SCHEMBL303703 0.69 CYP2A6 (0.40)
Aniline SCHEMBL6204639 0.69 TSHR (0.48)
Naphthoquinone SCHEMBL27590385 0.68 CDC25B (0.54) CA1CA2CA9ADORA3
Biphenyl SCHEMBL2199525 0.68 NOTUM (0.50)
Anthracene SCHEMBL27585398 0.66 ALDH1A1 (0.37)
Biphenyl SCHEMBL27870612 0.66 NOTUM (0.48)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1312986-A1 Magenta-colored toner particles for electrostatographic imaging NexPress Solutions LLC (US) 2003-05-21 EP disclosed
US-6528223-B1 Particle composition comprising binder polymer and specified dye having various substituents introduced into aromatic ring at thiazolyl 4-position, to avoid tendency toward dye crystallization NEXPRESS SOLUTIONS LLC 2003-03-04 US disclosed