Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7063373 | 0.88 | TP53 (0.38) | LMNAALDH1A1DDB1CRBNCHRM2 | |
| SCHEMBL18366039 | 0.76 | DDB1 (0.44) | ALDH1A1DDB1CRBNCHRM2OPRM1 | |
| SCHEMBL7064754 | 0.76 | CA12 (0.45) | ALDH1A1DDB1CRBNCHRM2OPRM1 | |
| SCHEMBL7064747 | 0.76 | CA12 (0.45) | ALDH1A1DDB1CRBNCHRM2OPRM1 | |
| SCHEMBL7340893 | 0.74 | ALDH1A1 (0.44) | LMNAALDH1A1DDB1CRBNCHRM2 | |
| SCHEMBL7062412 | 0.73 | DPP4 (0.36) | TSHRTDP1KMT2A | |
| SCHEMBL7501387 | 0.68 | ALOX15 (0.43) | LMNAALDH1A1TSHRTDP1HTT | |
| SCHEMBL8212856 | 0.68 | ALOX15 (0.43) | LMNAALDH1A1TSHRTDP1HTT | |
| SCHEMBL125972 | 0.66 | LMNA (0.71) | LMNAALDH1A1TSHRTDP1HTT | |
| SCHEMBL478339 | 0.66 | LMNA (0.71) | LMNAALDH1A1TSHRTDP1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0728746-B1 | Azepinone compounds useful in the inhibition of ACE and NEP | BRISTOL MYERS SQUIBB CO (US) | 2003-05-28 | — | — | EP | disclosed |
| US-6143886-A | CYCLOPROPYL-SUBSTITUTED AZEPINONE COMPOUNDS WHICH ARE USEFUL EITHER AS SELECTIVE ANGIOTENSIN CONVERTING ENZYME INHIBITORS, OR AS DUAL INHIBITORS OF BOTH ANGIOTENSIN CONVERTING ENZYME AND NEUTRAL ENDOPEPTIDASE | BRISTOL-MYERS SQUIBB CO. (US) | 2000-11-07 | — | — | US | disclosed |
| US-5994537-A | Process for preparing azepinone compounds useful in the inhibition of ACE and NEP | BRISTOL-MYERS SQUIBB CO. (US) | 1999-11-30 | — | — | US | disclosed |
| US-5587375-A | TREATING BLOOD PRESSURE, INTRAOCULAR PRESSURE, CARDIOVASCULAR DISORDERS, GLAUCOMA, AND RENAL DISEASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-24 | — | — | US | disclosed |
| EP-0728746-A1 | Azepinone compounds useful in the inhibition of ACE and NEP | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-08-28 | — | — | EP | disclosed |