Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.56 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | HTR5A | P47898 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TACR3 | P29371 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14863278 | 0.85 | HPGD (0.55) | HPGDPDCD1CD274GSK3BDYRK1A | |
| SCHEMBL108722 | 0.85 | GSK3B (0.42) | HPGDGSK3BDYRK1AALDH1A1HTT | |
| Hydrochloric Acid SCHEMBL2562060 | 0.84 | PDCD1 (0.44) | HPGDPDCD1CD274GSK3BDYRK1A | |
| SCHEMBL18601384 | 0.84 | TACR3 (0.48) | HPGDPDCD1CD274GSK3BDYRK1A | |
| SCHEMBL14863275 | 0.84 | ALDH1A1 (0.44) | HPGDPDCD1CD274GSK3BDYRK1A | |
| SCHEMBL2356064 | 0.83 | HPGD (0.56) | HPGDGSK3BDYRK1AKMT2AHTR2A | |
| SCHEMBL1203436 | 0.83 | GSK3B (0.56) | HPGDGSK3BDYRK1AALDH1A1HTR1A | |
| SCHEMBL18601388 | 0.83 | NR1H4 (0.46) | HPGDPDCD1CD274ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL2557288 | 0.83 | TACR3 (0.47) | HPGDPDCD1CD274GSK3BDYRK1A | |
| SCHEMBL928670 | 0.83 | MKNK1 (0.43) | HPGDKMT2AALDH1A1HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11261185-B2 | Bicyclic heterocyclic derivatives | MERCK PATENT GMBH (DE) | 2022-03-01 | — | — | US | disclosed |
| US-20210002278-A1 | BICYCLIC HETEROCYCLIC DERIVATIVES | MERCK PATENT GMBH (DE) | 2021-01-07 | — | — | US | disclosed |
| US-10829489-B2 | Bicyclic heterocyclic derivatives | MERCK PATENT GMBH (DE) | 2020-11-10 | — | — | US | disclosed |
| US-20200062756-A1 | BICYCLIC HETEROCYCLIC DERIVATIVES | MERCK PATENT GMBH (DE) | 2020-02-27 | — | — | US | disclosed |
| EP-3328857-B1 | BICYCLIC HETEROCYCLIC DERIVATIVES | MERCK PATENT GMBH (DE) | 2019-08-14 | — | — | EP | disclosed |
| US-20190010151-A1 | BICYCLIC HETEROCYCLIC DERIVATIVES | MERCK PATENT GMBH (DE) | 2019-01-10 | — | — | US | disclosed |
| EP-3328857-A1 | BICYCLIC HETEROCYCLIC DERIVATIVES | Merck Patent GmbH (DE) | 2018-06-06 | — | — | EP | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| US-9963463-B2 | Urea-substituted indanes as P38 map kinase inhibitors | TORRENT PHARMACEUTICALS LIMITED (IN) | 2018-05-08 | — | — | US | disclosed |
| US-20170247390-A1 | P38 MAP KINASE INHIBITING INDANYL UREA COMPOUNDS | TORRENT PHARMACEUTICALS LIMITED (IN) | 2017-08-31 | — | — | US | disclosed |
| US-20100009993-A1 | Diketo Fused Azolopiperidines and Azolopiperazines as Anti-HIV Agents | BRISTOL-MYERS SQUIBB COMPANY | 2010-01-14 | — | — | US | disclosed |
| US-20100009993-A1 | Diketo Fused Azolopiperidines and Azolopiperazines as Anti-HIV Agents | BRISTOL-MYERS SQUIBB COMPANY | 2010-01-14 | — | — | US | disclosed |
| US-20100009993-A1 | Diketo Fused Azolopiperidines and Azolopiperazines as Anti-HIV Agents | BRISTOL-MYERS SQUIBB COMPANY | 2010-01-14 | — | — | US | disclosed |
| WO-2009158394-A1 | DIKETO AZOLOPIPERIDINES AND AZOLOPIPERAZINES AS ANTI-HIV AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-12-30 | — | — | WO | disclosed |
| WO-2009158394-A1 | DIKETO AZOLOPIPERIDINES AND AZOLOPIPERAZINES AS ANTI-HIV AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-12-30 | — | — | WO | disclosed |
| WO-2009137462-A2 | METHODS FOR TREATING COGNITIVE DISORDERS USING INHIBITORS OF HISTONE DEACETYLASE | ENVIVO PHARMACEUTICALS, INC. (US) | 2009-11-12 | — | — | WO | disclosed |
| US-20080207590-A1 | Inhibitors of Histone Deacetylase | METHYLGENE INC. (CA) | 2008-08-28 | — | — | US | disclosed |
| US-20080207590-A1 | Inhibitors of Histone Deacetylase | METHYLGENE INC. (CA) | 2008-08-28 | — | — | US | disclosed |
| US-20080207590-A1 | Inhibitors of Histone Deacetylase | METHYLGENE INC. (CA) | 2008-08-28 | — | — | US | disclosed |
| WO-2008055068-A2 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2008-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210002278-A1 | BICYCLIC HETEROCYCLIC DERIVATIVES | PDK1, PDK2, PDK3 | HPGD 116/4885PDCD1 296/4885CD274 1161/4885 |
| US-20200062756-A1 | BICYCLIC HETEROCYCLIC DERIVATIVES | PDK1, PDK2, PDK3 | HPGD 116/4885PDCD1 296/4885CD274 1161/4885 |
| US-20170247390-A1 | P38 MAP KINASE INHIBITING INDANYL UREA COMPOUNDS | MAPK1, MAP3K11, MAPK3 | HPGD 1309/4885PDCD1 2436/4885CD274 4010/4885 |
| US-20080207590-A1 | Inhibitors of Histone Deacetylase | HDAC1, HDAC5, HDAC11 | HPGD 1873/4885PDCD1 2326/4885CD274 2598/4885 |
| US-10829489-B2 | Bicyclic heterocyclic derivatives | PDK1, PDK2, PDK3 | HPGD 116/4885PDCD1 296/4885CD274 1161/4885 |
| US-20100009993-A1 | Diketo Fused Azolopiperidines and Azolopiperazines as Anti-HIV Agents | DHFR, DHPS, DCK | HPGD 855/4885PDCD1 1235/4885CD274 2956/4885 |
| US-20190010151-A1 | BICYCLIC HETEROCYCLIC DERIVATIVES | PDK1, PDK2, PDK3 | HPGD 116/4885PDCD1 296/4885CD274 1161/4885 |
| US-11261185-B2 | Bicyclic heterocyclic derivatives | PDK1, PDK2, PDK3 | HPGD 116/4885PDCD1 296/4885CD274 1161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.