Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 12/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 7/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.55 |
| ▸ | LMNA | P02545 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7069975 | 0.90 | GAA (0.60) | PKMKMT2AGAASMN1; SMN2LMNA | |
| SCHEMBL7075108 | 0.88 | GAA (0.48) | PKMGAASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL7075993 | 0.87 | ATM (0.66) | PKMMEN1RAB9AKMT2AGAA | |
| SCHEMBL7076669 | 0.87 | GAA (0.53) | PKMKMT2AGAASMN1; SMN2LMNA | |
| SCHEMBL7076852 | 0.86 | MAPT (0.54) | PKMKMT2AGAASMN1; SMN2LMNA | |
| SCHEMBL7071584 | 0.85 | GAA (0.52) | PKMKMT2AGAASMN1; SMN2LMNA | |
| SCHEMBL7074071 | 0.85 | KDM4E (0.56) | PKMMEN1KMT2AGAASMN1; SMN2 | |
| SCHEMBL7070017 | 0.84 | DGAT1 (0.50) | PKMMEN1KMT2AGAASMN1; SMN2 | |
| SCHEMBL7654110 | 0.84 | LMNA (0.53) | PKMMEN1RAB9AKMT2AGAA | |
| SCHEMBL10064232 | 0.83 | PKM (0.74) | PKMMEN1RAB9AKMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025086-B1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 2003-06-25 | — | — | EP | disclosed |
| US-6492368-B1 | Benzamidine derivatives as factor XA inhibitors | MERCK PATENT GMBH (DE) | 2002-12-10 | — | — | US | disclosed |