Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | GAA | P10253 | 3/20 | 0.55 |
| ▸ | PKM | P14618 | 5/20 | 0.53 |
| ▸ | F10 | P00742 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | MGLL | Q99685 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7070562 | 0.90 | F10 (0.57) | ATMF10 | |
| SCHEMBL7071582 | 0.89 | LMNA (0.60) | ATMSMN1; SMN2ALDH1A1GAALMNA | |
| SCHEMBL7075122 | 0.89 | LMNA (0.65) | SMN1; SMN2ALDH1A1LMNAUSP2TSHR | |
| SCHEMBL7074172 | 0.87 | SMN1; SMN2 (0.56) | ATMSMN1; SMN2ALDH1A1GAALMNA | |
| SCHEMBL7074664 | 0.87 | THRB (0.53) | ATMSMN1; SMN2ALDH1A1GAAF10 | |
| SCHEMBL7069359 | 0.87 | THRB (0.48) | ATMSMN1; SMN2ALDH1A1GAAF10 | |
| SCHEMBL7069977 | 0.87 | PKM (0.55) | ATMSMN1; SMN2ALDH1A1GAAPKM | |
| SCHEMBL7654110 | 0.87 | LMNA (0.53) | ATMSMN1; SMN2ALDH1A1GAAPKM | |
| SCHEMBL7074222 | 0.87 | LMNA (0.62) | SMN1; SMN2ALDH1A1GAALMNAKMT2A | |
| SCHEMBL7076687 | 0.86 | TSHR (0.59) | ALDH1A1GAALMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025086-B1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 2003-06-25 | — | — | EP | disclosed |
| US-6492368-B1 | Benzamidine derivatives as factor XA inhibitors | MERCK PATENT GMBH (DE) | 2002-12-10 | — | — | US | disclosed |