Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 1/20 | 0.57 |
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
| ▸ | CCR3 | P51677 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | MMP13 | P45452 | 4/20 | 0.48 |
| ▸ | MMP2 | P08253 | 3/20 | 0.48 |
| ▸ | USP5 | P45974 | 1/20 | 0.48 |
| ▸ | FPR2 | P25090 | 4/20 | 0.47 |
| ▸ | PROKR1 | Q8TCW9 | 4/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.46 |
| ▸ | MMP12 | P39900 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7076370 | 0.89 | MMP2 (0.53) | ACLYMMP13MMP2USP5FPR2 | |
| SCHEMBL7076681 | 0.83 | ACLY (0.60) | ACLYHRH1CCR3KCNH2MMP13 | |
| SCHEMBL7073733 | 0.78 | MAPT (0.49) | PTGDR | |
| SCHEMBL7074343 | 0.78 | MMP2 (0.76) | ACLYHRH1CCR3KCNH2MMP13 | |
| SCHEMBL7076424 | 0.78 | MMP2 (0.61) | ACLYMMP13MMP2FPR2PROKR1 | |
| SCHEMBL7076372 | 0.77 | ACLY (0.53) | ACLYHRH1CCR3MMP13MMP2 | |
| SCHEMBL7072144 | 0.76 | HRH1 (0.49) | ACLYHRH1CCR3KCNH2MMP13 | |
| SCHEMBL7072432 | 0.74 | CNR1 (0.48) | ACLYCNR1PTGDR | |
| SCHEMBL22003915 | 0.73 | ACLY (1.00) | ACLYUSP5FPR2PROKR1EPHX2 | |
| SCHEMBL4752293 | 0.73 | FPR2 (0.57) | ACLYHRH1CCR3MMP13FPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030022893-A1 | Hydroxamic and carboxylic acid derivatives | BAXTER ANDREW DOUGLAS (GB) | 2003-01-30 | — | — | US | claimed |
| US-20030022893-A1 | Hydroxamic and carboxylic acid derivatives | BAXTER ANDREW DOUGLAS (GB) | 2003-01-30 | — | — | US | disclosed |
| US-6465468-B1 | SUCH AS N-HYDROXY-2-(4-(4-CHLOROPHENYL)PIPERAZINE-1-SULFONYL)BENZAMIDE; INHIBITORS OF MATRIX METALLOPROTEINASE, ADAM OR ADAMTS ENZYMES; TREATMENT OF DEGENERATIVE DISEASES AND CERTAIN CANCERS | DARWIN DISCOVERY LIMITED (GB) | 2002-10-15 | — | — | US | disclosed |
| EP-1163213-A1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES | Darwin Discovery Limited (GB) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000056704-A1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES | DARWIN DISCOVERY LIMITED (GB) | 2000-09-28 | — | — | WO | disclosed |