Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 1/20 | 0.53 |
| ▸ | FPR2 | P25090 | 6/20 | 0.48 |
| ▸ | PROKR1 | Q8TCW9 | 6/20 | 0.48 |
| ▸ | MMP13 | P45452 | 5/20 | 0.47 |
| ▸ | MMP2 | P08253 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | CCR3 | P51677 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7076681 | 0.79 | ACLY (0.60) | ACLYFPR2PROKR1MMP13MMP2 | |
| SCHEMBL7076690 | 0.79 | MAPT (0.53) | ACLYSMN1; SMN2MAPT | |
| SCHEMBL7076424 | 0.79 | MMP2 (0.61) | ACLYFPR2PROKR1MMP13MMP2 | |
| SCHEMBL7072306 | 0.77 | ACLY (0.57) | ACLYFPR2PROKR1MMP13MMP2 | |
| SCHEMBL7074343 | 0.77 | MMP2 (0.76) | ACLYFPR2PROKR1MMP13MMP2 | |
| SCHEMBL7077688 | 0.75 | ALDH1A1 (0.51) | SMN1; SMN2MAPTFAAHEPHX2 | |
| SCHEMBL7076370 | 0.74 | MMP2 (0.53) | ACLYFPR2PROKR1MMP13MMP2 | |
| SCHEMBL7077516 | 0.72 | HTT (0.42) | ACLYSMN1; SMN2MAPT | |
| SCHEMBL8363776 | 0.72 | MMP2 (0.60) | ACLYFPR2PROKR1MMP13MMP2 | |
| SCHEMBL4752293 | 0.71 | FPR2 (0.57) | ACLYFPR2PROKR1MMP13SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030022893-A1 | Hydroxamic and carboxylic acid derivatives | BAXTER ANDREW DOUGLAS (GB) | 2003-01-30 | — | — | US | claimed |
| US-6465468-B1 | SUCH AS N-HYDROXY-2-(4-(4-CHLOROPHENYL)PIPERAZINE-1-SULFONYL)BENZAMIDE; INHIBITORS OF MATRIX METALLOPROTEINASE, ADAM OR ADAMTS ENZYMES; TREATMENT OF DEGENERATIVE DISEASES AND CERTAIN CANCERS | DARWIN DISCOVERY LIMITED (GB) | 2002-10-15 | — | — | US | claimed |
| US-20030022893-A1 | Hydroxamic and carboxylic acid derivatives | BAXTER ANDREW DOUGLAS (GB) | 2003-01-30 | — | — | US | disclosed |
| US-6465468-B1 | SUCH AS N-HYDROXY-2-(4-(4-CHLOROPHENYL)PIPERAZINE-1-SULFONYL)BENZAMIDE; INHIBITORS OF MATRIX METALLOPROTEINASE, ADAM OR ADAMTS ENZYMES; TREATMENT OF DEGENERATIVE DISEASES AND CERTAIN CANCERS | DARWIN DISCOVERY LIMITED (GB) | 2002-10-15 | — | — | US | disclosed |