Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 5/20 | 0.53 |
| ▸ | MMP13 | P45452 | 5/20 | 0.53 |
| ▸ | ACLY | P53396 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | FPR2 | P25090 | 4/20 | 0.45 |
| ▸ | PROKR1 | Q8TCW9 | 4/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7072306 | 0.89 | ACLY (0.57) | MMP2MMP13ACLYEPHX2CYP2C9 | |
| SCHEMBL7074343 | 0.82 | MMP2 (0.76) | MMP2MMP13ACLYFAAHFPR2 | |
| SCHEMBL7076689 | 0.80 | MAPT (0.49) | MMP2MMP13HDAC3HDAC4HDAC1 | |
| SCHEMBL7076735 | 0.79 | EPHX2 (0.51) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL7076740 | 0.79 | EPHX2 (0.51) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL7076681 | 0.78 | ACLY (0.60) | MMP2MMP13ACLYEPHX2FAAH | |
| SCHEMBL7076424 | 0.78 | MMP2 (0.61) | MMP2MMP13ACLYFAAHFPR2 | |
| SCHEMBL7077511 | 0.78 | HDAC3 (0.54) | MMP2MMP13HDAC3HDAC4HDAC1 | |
| SCHEMBL7074348 | 0.76 | MMP13 (0.53) | MMP2MMP13ACLYEPHX2CYP2C9 | |
| SCHEMBL7074119 | 0.75 | HDAC3 (0.46) | MMP2MMP13ACLYHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030022893-A1 | Hydroxamic and carboxylic acid derivatives | BAXTER ANDREW DOUGLAS (GB) | 2003-01-30 | — | — | US | claimed |
| US-6465468-B1 | SUCH AS N-HYDROXY-2-(4-(4-CHLOROPHENYL)PIPERAZINE-1-SULFONYL)BENZAMIDE; INHIBITORS OF MATRIX METALLOPROTEINASE, ADAM OR ADAMTS ENZYMES; TREATMENT OF DEGENERATIVE DISEASES AND CERTAIN CANCERS | DARWIN DISCOVERY LIMITED (GB) | 2002-10-15 | — | — | US | claimed |
| US-20030022893-A1 | Hydroxamic and carboxylic acid derivatives | BAXTER ANDREW DOUGLAS (GB) | 2003-01-30 | — | — | US | disclosed |
| US-6465468-B1 | SUCH AS N-HYDROXY-2-(4-(4-CHLOROPHENYL)PIPERAZINE-1-SULFONYL)BENZAMIDE; INHIBITORS OF MATRIX METALLOPROTEINASE, ADAM OR ADAMTS ENZYMES; TREATMENT OF DEGENERATIVE DISEASES AND CERTAIN CANCERS | DARWIN DISCOVERY LIMITED (GB) | 2002-10-15 | — | — | US | disclosed |
| EP-1163213-A1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES | Darwin Discovery Limited (GB) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000056704-A1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES | DARWIN DISCOVERY LIMITED (GB) | 2000-09-28 | — | — | WO | disclosed |