Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.71 |
| ▸ | MAPT | P10636 | 7/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.71 |
| ▸ | MEN1 | O00255 | 6/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.71 |
| ▸ | TP53 | P04637 | 4/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.71 |
| ▸ | CYP1A1 | P04798 | 4/20 | 0.71 |
| ▸ | CYP1B1 | Q16678 | 4/20 | 0.71 |
| ▸ | IP6K2 | Q9UHH9 | 4/20 | 0.71 |
| ▸ | FLT3 | P36888 | 4/20 | 0.71 |
| ▸ | GABRP | O00591 | 4/20 | 0.71 |
| ▸ | GABRD | O14764 | 4/20 | 0.71 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.71 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2874033 | 0.89 | POLH (0.79) | KMT2AMAPTKDM4ECYP3A4MEN1 | |
| SCHEMBL14917316 | 0.87 | POLH (0.81) | KMT2AMAPTKDM4ECYP3A4MEN1 | |
| Apigenin SCHEMBL29351464 | 0.83 | KMT2A (1.00) | KMT2AMAPTKDM4ECYP3A4MEN1 | |
| Apigenin SCHEMBL19428 | 0.83 | KMT2A (1.00) | KMT2AMAPTKDM4ECYP3A4MEN1 | |
| Apigenin SCHEMBL5083245 | 0.83 | KMT2A (1.00) | KMT2AMAPTKDM4ECYP3A4MEN1 | |
| Apigenin SCHEMBL31168790 | 0.82 | KMT2A (0.97) | KMT2AMAPTKDM4ECYP3A4MEN1 | |
| Apigenin SCHEMBL29872582 | 0.82 | KMT2A (0.97) | KMT2AMAPTKDM4ECYP3A4MEN1 | |
| Apigenin SCHEMBL31477961 | 0.82 | KMT2A (0.97) | KMT2AMAPTKDM4ECYP3A4MEN1 | |
| Apigenin SCHEMBL1658882 | 0.82 | KMT2A (0.97) | KMT2AMAPTKDM4ECYP3A4MEN1 | |
| Apigenin SCHEMBL29458838 | 0.82 | KMT2A (0.97) | KMT2AMAPTKDM4ECYP3A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1007528-B1 | ROBUSTAFLAVONE, INTERMEDIATES AND ANALOGUES AND METHOD FOR PREPARATION THEREOF | ADVANCED LIFE SCIENCES INC (US) | 2003-11-26 | — | — | EP | disclosed |
| EP-1007528-B1 | ROBUSTAFLAVONE, INTERMEDIATES AND ANALOGUES AND METHOD FOR PREPARATION THEREOF | ADVANCED LIFE SCIENCES INC (US) | 2003-11-26 | — | — | EP | disclosed |
| US-6225481-B1 | REACTING 6-IODO-5,7,4'-TRIMETHOXYFLAVONE AND 5,7-4'-TRIMETHOXY-3'-(TRIMETHYLSTANNYL)FLAVONE IN PRESENCE OF PALLADIUM COMPOUND AND BASE TO PRODUCE ROBUSTAFLAVONE HEXAMETHYL ETHER, DEMETHYLATING TO PRODUCE ROBUSTAFLAVONE | ADVANCED LIFE SCIENCES, INC. | 2001-05-01 | — | — | US | disclosed |
| US-6225481-B1 | REACTING 6-IODO-5,7,4'-TRIMETHOXYFLAVONE AND 5,7-4'-TRIMETHOXY-3'-(TRIMETHYLSTANNYL)FLAVONE IN PRESENCE OF PALLADIUM COMPOUND AND BASE TO PRODUCE ROBUSTAFLAVONE HEXAMETHYL ETHER, DEMETHYLATING TO PRODUCE ROBUSTAFLAVONE | ADVANCED LIFE SCIENCES, INC. | 2001-05-01 | — | — | US | disclosed |
| CN-1274354-A | Robustaflavone, intermediates and analogues and method for prepn. method | MEDICHEM RES INC (US) | 2000-11-22 | — | — | CN | disclosed |
| EP-1007528-A2 | ROBUSTAFLAVONE, INTERMEDIATES AND ANALOGUES AND METHOD FOR PREPARATION THEREOF | MEDICHEM RESEARCH, INC. (US) | 2000-06-14 | — | — | EP | disclosed |
| EP-1007528-A2 | ROBUSTAFLAVONE, INTERMEDIATES AND ANALOGUES AND METHOD FOR PREPARATION THEREOF | MEDICHEM RESEARCH, INC. (US) | 2000-06-14 | — | — | EP | disclosed |
| WO-1999010292-A3 | ROBUSTAFLAVONE, INTERMEDIATES AND ANALOGUES AND METHOD FOR PREPARATION THEREOF | MEDICHEM RES INC (US) | 1999-06-17 | — | — | WO | disclosed |
| WO-1999010292-A2 | ROBUSTAFLAVONE, INTERMEDIATES AND ANALOGUES AND METHOD FOR PREPARATION THEREOF | MEDICHEM RESEARCH, INC. (US) | 1999-03-04 | — | — | WO | disclosed |
| WO-1999010292-A2 | ROBUSTAFLAVONE, INTERMEDIATES AND ANALOGUES AND METHOD FOR PREPARATION THEREOF | MEDICHEM RESEARCH, INC. (US) | 1999-03-04 | — | — | WO | disclosed |