Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | GAA | P10253 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | F10 | P00742 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7070562 | 0.86 | F10 (0.57) | F10F2 | |
| SCHEMBL7076926 | 0.85 | LSS (0.52) | LMNAALDH1A1SMN1; SMN2POLBMAPT | |
| SCHEMBL7648189 | 0.83 | LMNA (0.53) | LMNAGAAHTTSMN1; SMN2POLB | |
| SCHEMBL7069977 | 0.82 | PKM (0.55) | PKMLMNAALDH1A1GAAHTT | |
| SCHEMBL7649437 | 0.82 | PKM (0.46) | PKMLMNAALDH1A1GAASMN1; SMN2 | |
| SCHEMBL7075108 | 0.81 | GAA (0.48) | PKMLMNAALDH1A1GAASMN1; SMN2 | |
| SCHEMBL7070020 | 0.81 | MAPT (0.59) | LMNAALDH1A1SMN1; SMN2POLBMAPT | |
| SCHEMBL5736725 | 0.81 | F10 (0.60) | PKMLMNAALDH1A1GAAHTT | |
| SCHEMBL5736557 | 0.81 | GAA (0.63) | PKMLMNAALDH1A1GAAHTT | |
| SCHEMBL7653773 | 0.80 | ALDH1A1 (0.44) | PKMLMNAALDH1A1HTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025086-B1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 2003-06-25 | — | — | EP | disclosed |
| US-6492368-B1 | Benzamidine derivatives as factor XA inhibitors | MERCK PATENT GMBH (DE) | 2002-12-10 | — | — | US | disclosed |