Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | ALPL | P05186 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7074280 | 0.91 | LMNA (0.57) | MEN1KMT2ACYP3A4CYP2C19CYP2C9 | |
| SCHEMBL7071363 | 0.90 | MAPT (0.53) | MEN1KMT2ACYP3A4CYP2C19CYP2C9 | |
| SCHEMBL7074464 | 0.84 | POLB (0.59) | KMT2AMAPTPOLBLMNAGAA | |
| SCHEMBL7075338 | 0.83 | THRB (0.58) | MEN1KMT2AALDH1A1MAPTPOLB | |
| SCHEMBL7071746 | 0.83 | MEN1 (0.54) | MEN1KMT2ACYP2C19CYP2C9ALDH1A1 | |
| SCHEMBL7070562 | 0.83 | F10 (0.57) | — | |
| SCHEMBL7071596 | 0.81 | LMNA (0.54) | MEN1KMT2ACYP2C19CYP2C9ALDH1A1 | |
| SCHEMBL7076931 | 0.81 | MGLL (0.53) | KMT2ACYP2C19CYP2C9ALDH1A1MAPT | |
| SCHEMBL8075892 | 0.80 | THRB (0.54) | MEN1KMT2AALDH1A1MAPTPOLB | |
| SCHEMBL7069983 | 0.79 | LMNA (0.58) | ALDH1A1MAPTPOLBRAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025086-B1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 2003-06-25 | — | — | EP | disclosed |
| US-6492368-B1 | Benzamidine derivatives as factor XA inhibitors | MERCK PATENT GMBH (DE) | 2002-12-10 | — | — | US | disclosed |