Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MGLL | Q99685 | 2/20 | 0.49 |
| ▸ | CNR2 | P34972 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8075892 | 0.96 | THRB (0.54) | THRBLMNAMAPTMGLLCNR2 | |
| SCHEMBL7074664 | 0.88 | THRB (0.53) | THRBLMNAMAPTMGLLATM | |
| SCHEMBL7071363 | 0.87 | MAPT (0.53) | THRBLMNAMAPTMGLLALDH1A1 | |
| SCHEMBL7076931 | 0.85 | MGLL (0.53) | THRBLMNAMAPTMGLLALDH1A1 | |
| SCHEMBL7069359 | 0.84 | THRB (0.48) | THRBLMNAMGLLATMALDH1A1 | |
| SCHEMBL7071746 | 0.84 | MEN1 (0.54) | LMNAMGLLPOLBALDH1A1KMT2A | |
| SCHEMBL7076839 | 0.84 | KMT2A (0.59) | THRBLMNAMAPTMGLLPOLB | |
| SCHEMBL7074158 | 0.83 | MEN1 (0.68) | THRBLMNAMAPTPOLBALDH1A1 | |
| SCHEMBL7074799 | 0.83 | MGLL (0.55) | THRBLMNAMGLLALDH1A1MAPK1 | |
| SCHEMBL7071596 | 0.82 | LMNA (0.54) | THRBLMNAMAPTMGLLPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025086-B1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 2003-06-25 | — | — | EP | disclosed |
| US-6492368-B1 | Benzamidine derivatives as factor XA inhibitors | MERCK PATENT GMBH (DE) | 2002-12-10 | — | — | US | disclosed |