Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | LMNA | P02545 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | CASP1 | P29466 | 1/20 | 0.53 |
| ▸ | CASP7 | P55210 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7069983 | 0.87 | LMNA (0.58) | POLBMAPTLMNA | |
| SCHEMBL7076852 | 0.87 | MAPT (0.54) | POLBGAAMAPTLMNAKMT2A | |
| SCHEMBL7074280 | 0.86 | LMNA (0.57) | POLBGAALMNAKMT2ATHRB | |
| SCHEMBL7074664 | 0.85 | THRB (0.53) | GAAMAPTLMNAKMT2ATHRB | |
| SCHEMBL7069359 | 0.85 | THRB (0.48) | GAALMNAKMT2ATHRBTP53 | |
| SCHEMBL7074222 | 0.85 | LMNA (0.62) | GAALMNAKMT2ATHRBMAPK1 | |
| SCHEMBL7076713 | 0.85 | RAB9A (0.54) | POLBMAPTLMNAKMT2ATHRB | |
| SCHEMBL7075993 | 0.85 | ATM (0.66) | GAAMAPTLMNAKMT2AUSP2 | |
| SCHEMBL7074158 | 0.84 | MEN1 (0.68) | POLBGAAMAPTLMNAKMT2A | |
| SCHEMBL8080659 | 0.84 | LMNA (0.55) | POLBMAPTLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025086-B1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 2003-06-25 | — | — | EP | disclosed |
| US-6492368-B1 | Benzamidine derivatives as factor XA inhibitors | MERCK PATENT GMBH (DE) | 2002-12-10 | — | — | US | disclosed |