Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 8/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7073767 | 0.89 | MMP13 (0.49) | MMP13F2ALDH1A1MMP1MMP2 | |
| SCHEMBL7078927 | 0.85 | CA12 (0.44) | MMP13F2ALDH1A1KDM4EHTT | |
| SCHEMBL7077769 | 0.84 | HSD17B10 (0.39) | MMP13F2ALDH1A1MMP1MMP2 | |
| SCHEMBL7078046 | 0.83 | DHODH (0.42) | MMP13ALDH1A1KDM4EMMP2CA12 | |
| SCHEMBL7074900 | 0.82 | F2 (0.45) | F2ALDH1A1F10HSD11B1KMT2A | |
| SCHEMBL7136267 | 0.80 | SCN1A (0.43) | MMP13ALDH1A1HTTKMT2AGAA | |
| SCHEMBL7077837 | 0.79 | ALDH1A1 (0.45) | MMP13F2ALDH1A1MMP2F10 | |
| SCHEMBL7075400 | 0.77 | F2 (0.45) | MMP13F2ALDH1A1KDM4EMMP2 | |
| SCHEMBL7078814 | 0.77 | MMP13 (0.48) | MMP13F2ALDH1A1MMP1MMP2 | |
| SCHEMBL6774874 | 0.76 | F10 (0.43) | F2ALDH1A1F10HSD11B1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003059872-A1 | AVB3 AND AVB5 INTEGRIN ANTAGONISTS AND METHODS OF TREATING DISEASES OR CONDITIONS ASSOCIATED WITH AVB3 AND AVB5 INTEGRINS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-07-24 | — | — | WO | disclosed |
| WO-2003059872-A1 | AVB3 AND AVB5 INTEGRIN ANTAGONISTS AND METHODS OF TREATING DISEASES OR CONDITIONS ASSOCIATED WITH AVB3 AND AVB5 INTEGRINS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-07-24 | — | — | WO | disclosed |