Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CASR | P41180 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MMP13 | P45452 | 7/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7077549 | 0.92 | DHODH (0.44) | DHODHMMP2MMP8CA12CA9 | |
| SCHEMBL7130423 | 0.89 | RORC (0.44) | DHODHMMP2MMP8RORCALDH1A1 | |
| SCHEMBL7078927 | 0.87 | CA12 (0.44) | MMP2CA12CA9CA1CA2 | |
| SCHEMBL7074308 | 0.83 | MMP13 (0.45) | MMP2CA12CA9CA1CA2 | |
| SCHEMBL7078041 | 0.80 | RORC (0.47) | DHODHMMP2MMP8RORCALDH1A1 | |
| SCHEMBL7136267 | 0.80 | SCN1A (0.43) | ALDH1A1MMP13LMNAMAPTHSD17B10 | |
| SCHEMBL7078136 | 0.80 | MMP2 (0.58) | DHODHMMP2MMP8CA12CA9 | |
| SCHEMBL7077769 | 0.79 | HSD17B10 (0.39) | MMP2ALDH1A1MMP13HSD17B10 | |
| SCHEMBL8360105 | 0.77 | RORC (0.43) | DHODHMMP2MMP8CA12CA9 | |
| SCHEMBL7074900 | 0.77 | F2 (0.45) | MMP8ALDH1A1LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003059872-A1 | AVB3 AND AVB5 INTEGRIN ANTAGONISTS AND METHODS OF TREATING DISEASES OR CONDITIONS ASSOCIATED WITH AVB3 AND AVB5 INTEGRINS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-07-24 | — | — | WO | disclosed |