Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | PLA2G2A | P14555 | 9/20 | 0.49 |
| ▸ | MGLL | Q99685 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7074575 | 0.87 | HDAC4 (0.48) | LMNATSHRALDH1A1SMN1; SMN2PLA2G2A | |
| SCHEMBL7074002 | 0.82 | LMNA (0.54) | LMNASMN1; SMN2PLA2G2AMGLLHTT | |
| SCHEMBL7075196 | 0.82 | MGLL (0.54) | LMNATSHRALDH1A1MGLLHDAC4 | |
| SCHEMBL7070015 | 0.81 | LMNA (0.57) | LMNASMN1; SMN2PLA2G2AMGLLHTT | |
| SCHEMBL7073717 | 0.81 | TSHR (0.57) | LMNATSHRALDH1A1SMN1; SMN2MGLL | |
| SCHEMBL8080502 | 0.81 | LMNA (0.44) | LMNATSHRALDH1A1SMN1; SMN2GLA | |
| SCHEMBL7074530 | 0.80 | THRB (0.52) | LMNASMN1; SMN2THRBNPC1HTT | |
| SCHEMBL7069910 | 0.79 | MGLL (0.52) | LMNATSHRMGLLHDAC4HDAC2 | |
| SCHEMBL7070564 | 0.78 | LMNA (0.49) | LMNAALDH1A1SMN1; SMN2MGLLTHRB | |
| SCHEMBL7648125 | 0.78 | PLA2G2A (0.56) | PLA2G2AMGLLHDAC4HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025086-B1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 2003-06-25 | — | — | EP | disclosed |
| US-6492368-B1 | Benzamidine derivatives as factor XA inhibitors | MERCK PATENT GMBH (DE) | 2002-12-10 | — | — | US | disclosed |
| EP-1025086-A1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GmbH (DE) | 2000-08-09 | — | — | EP | disclosed |
| WO-1999016751-A1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 1999-04-08 | — | — | WO | disclosed |