Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 4/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3074024 | 0.80 | DGAT1 (0.58) | THRBDGAT1LMNANPC1RAB9A | |
| SCHEMBL7077520 | 0.80 | LMNA (0.54) | THRBLMNAHTTNPC1RAB9A | |
| SCHEMBL7387750 | 0.79 | GRM2 (0.45) | THRBLMNAHTTNPC1RAB9A | |
| SCHEMBL7070226 | 0.79 | THRB (0.54) | THRBDGAT1LMNAHTTMAPT | |
| SCHEMBL7074575 | 0.78 | HDAC4 (0.48) | THRBDGAT1LMNAHTTNPC1 | |
| SCHEMBL7070001 | 0.76 | THRB (0.63) | THRBDGAT1LMNAHTTRAB9A | |
| SCHEMBL7075210 | 0.76 | THRB (0.57) | THRBDGAT1LMNAHTTMAPT | |
| SCHEMBL4810836 | 0.74 | POLB (0.59) | MAPTPOLBKDM4ETP53 | |
| SCHEMBL7071891 | 0.74 | THRB (0.63) | THRBDGAT1LMNARAB9AMAPT | |
| SCHEMBL7073990 | 0.74 | THRB (0.56) | THRBDGAT1LMNAHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025086-B1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 2003-06-25 | — | — | EP | disclosed |
| US-6492368-B1 | Benzamidine derivatives as factor XA inhibitors | MERCK PATENT GMBH (DE) | 2002-12-10 | — | — | US | disclosed |