Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 3/20 | 0.39 |
| ▸ | NCF1 | P14598 | 2/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.39 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 6/20 | 0.34 |
| ▸ | HTR3A | P46098 | 6/20 | 0.34 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cadaverine Tartrate SCHEMBL7075916 | 0.91 | NCF1 (0.35) | ADRB1NCF1ADRB2PRKCZTAAR1 | |
| SCHEMBL7076057 | 0.80 | TAAR1 (0.40) | ADRB1NCF1ADRB2TAAR1HTR2A | |
| SCHEMBL7071736 | 0.77 | KDM4E (0.38) | CRHR1KDM4EALDH1A1CASP1CASP7 | |
| SCHEMBL7215494 | 0.77 | KDM4E (0.38) | CRHR1KDM4EALDH1A1CASP1CASP7 | |
| SCHEMBL7681552 | 0.77 | NCF1 (0.52) | ADRB1NCF1ADRB2HTR2AHTR2C | |
| SCHEMBL7684787 | 0.76 | NCF1 (0.55) | ADRB1NCF1ADRB2HTR2AHTR2C | |
| SCHEMBL7621565 | 0.75 | ADRB1 (0.43) | ADRB1NCF1ADRB2TAAR1HTR2A | |
| SCHEMBL7079153 | 0.74 | CRHR1 (0.36) | CRHR1KDM4EALDH1A1CASP1CASP7 | |
| Cadaverine Tartrate SCHEMBL7075912 | 0.72 | HTR6 (0.36) | ADRB1NCF1ADRB2TAAR1HTR2A | |
| SCHEMBL7981205 | 0.72 | CRHR1 (0.35) | CRHR1KDM4EALDH1A1CASP1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030105117-A1 | Aminoalkyl substituted 5,6,7,8-tetrahydro-9H-pyridino[2,3-b]indole and 5,6,7,8-tetrahydro-9H-pyrimidino[4,5-b]indole derivatives: CRF1 specific ligands | NEUROGEN CORPORATION | 2003-06-05 | — | — | US | disclosed |
| US-6472402-B1 | Aminoalkyl substituted 5,6,7,8-Tetrahydro-9H-Pyridino [2,3-B]indole derivatives | NEUROGEN CORPORATION | 2002-10-29 | — | — | US | disclosed |
| US-6291473-B1 | TREATING ANXIETY, DEPRESSION, POST-TRAUMATIC STRESS DISORDER, INFLAMMATORY DISEASES, OBESITY, IN MAMMALS | NEUROGEN CORPORATION | 2001-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030105117-A1 | Aminoalkyl substituted 5,6,7,8-tetrahydro-9H-pyridino[2,3-b]indole and 5,6,7,8-tetrahydro-9H-pyrimidino[4,5-b]indole derivatives: CRF1 specific ligands | GPR119, CRHR1, IRS1 | ADRB1 16/4885NCF1 3525/4885ADRB2 91/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.